PIPERIDINE-4-CARBOXYLIC ACID 4-CHLORO-BENZYLAMIDE

Base Information

• Chemical Name: PIPERIDINE-4-CARBOXYLIC ACID 4-CHLORO-BENZYLAMIDE
• CAS No.: 885274-77-1
• Molecular Formula: C₁₃H₁₇ClN₂O
• Molecular Weight: 252.744
• Hs Code.: 2933399090
• Mol file: 885274-77-1.mol

Synonyms:PIPERIDINE-4-CARBOXYLIC ACID 4-CHLORO-BENZYLAMIDE

Chemical Property of PIPERIDINE-4-CARBOXYLIC ACID 4-CHLORO-BENZYLAMIDE

Chemical Property:

• PSA: 41.13000
• LogP: 2.67550
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Piperidine-4-carboxylicacid4-chloro-benzylamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDINE-4-CARBOXYLIC ACID 4-CHLORO-BENZYLAMIDE

There total 3 articles about PIPERIDINE-4-CARBOXYLIC ACID 4-CHLORO-BENZYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(4-chlorobenzylcarbamoyl)piperidine-1-carboxylate (881833-22-3) → C13H17ClN2O (885274-77-1)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.11.013

Reference yield:

4-chlorobenzylamine (104-86-9) → C13H17ClN2O (885274-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; ethyl acetate;

DOI:10.1016/j.ejmech.2013.11.013

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → C13H17ClN2O (885274-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; ethyl acetate;

DOI:10.1016/j.ejmech.2013.11.013

upstream raw materials:

4-chlorobenzylamine

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

tert-butyl 4-(4-chlorobenzylcarbamoyl)piperidine-1-carboxylate

Refernces