METHYL-3-BROMOINDAZOLE-4-CARBOXYLATE

Base Information

• Chemical Name: METHYL-3-BROMOINDAZOLE-4-CARBOXYLATE
• CAS No.: 885271-63-6
• Molecular Formula: C9H7 Br N2 O2
• Molecular Weight: 255.071
• Hs Code.: 2933990090
• Mol file: 885271-63-6.mol

Synonyms:Methyl 3-bromo-1H-indazole-4-carboxylate;Methyl 3-broMo-1H-indazol...;3-BroMo-1H-indazole-5-caboxylic acid Methylester;3-Bromo-4-(methoxycarbonyl)-1H-indazole

Chemical Property of METHYL-3-BROMOINDAZOLE-4-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 1.35E-06mmHg at 25°C
• Refractive Index: 1.675
• Boiling Point: 399.7°C at 760 mmHg
• PKA: 10.25±0.40(Predicted)
• Flash Point: 195.5°C
• PSA: 54.98000
• Density: 1.709g/cm³
• LogP: 2.11200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl-3-bromoindazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-3-BROMOINDAZOLE-4-CARBOXYLATE

There total 3 articles about METHYL-3-BROMOINDAZOLE-4-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1H-indazole-4-carboxylic acid methyl ester (192945-49-6) → 3-bromo-1H-indazole-4-carboxylic acid methyl ester (885271-63-6)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

1H-indazole-4-carboxylic acid (677306-38-6) → 3-bromo-1H-indazole-4-carboxylic acid methyl ester (885271-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; toluene / 20 °C

2: N-Bromosuccinimide; potassium hydroxide / N,N-dimethyl-formamide / 1 h

With N-Bromosuccinimide; potassium hydroxide; In methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

methyl 3-amino-2-methylbenzoate (18583-89-6) → 3-bromo-1H-indazole-4-carboxylic acid methyl ester (885271-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; acetic acid / 1 h / 25 °C / Inert atmosphere

2: potassium hydroxide; N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 25 °C / Inert atmosphere

With N-Bromosuccinimide; acetic acid; potassium hydroxide; sodium nitrite; In N,N-dimethyl-formamide;

upstream raw materials:

1H-indazole-4-carboxylic acid methyl ester

1H-indazole-4-carboxylic acid

methyl 3-amino-2-methylbenzoate

Refernces

• 1、 -. "Amino pyrazine compound and application thereof". Sheet 0214; 0215; 0216; 0217; 0218. . Retrieved 2016/12/22.