Methylcyclohexylacetamide

Base Information

• Chemical Name: Methylcyclohexylacetamide
• CAS No.: 28523-32-2
• Molecular Formula: C₉H₁₇NO
• Molecular Weight: 155.24
• DSSTox Substance ID: DTXSID401309172
• Mol file: 28523-32-2.mol

Synonyms:methylcyclohexylacetamide;SCHEMBL885301;alpha-Methylcyclohexaneacetamide;DTXSID401309172;28523-32-2

Chemical Property of Methylcyclohexylacetamide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 155.131014166
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1CCCCC1)C(=O)N

Technology Process of Methylcyclohexylacetamide

There total 8 articles about Methylcyclohexylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(S)-2-Phenylpropionic acid (7782-24-3) → ethyl-cyclohexane (1678-91-7) + 2-cyclohexylpropanamide (28523-32-2) + 2-cyclohexylpropan-1-amine (103254-49-5)

Guidance literature:

(S)-2-Phenylpropionic acid; With cyclopentyl methyl ether; ammonia; at 200 ℃; under 4500.45 Torr; Sealed tube; Green chemistry;

With cyclopentyl methyl ether; ammonia; hydrogen; at 200 ℃; for 14h; under 42004.2 Torr; Cooling with ice; Green chemistry;

DOI:10.1039/d0gc01441a

Reference yield:

2-(Cyclohexen-(1)-yl)-propen-(2)-saeureamid (16933-69-0) → 2-cyclohexylpropanamide (28523-32-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01272a005

Reference yield:

vinylidenecyclohexane (5664-20-0) → 2-cyclohexylpropanamide (28523-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: H₂ / Pd-C / ethanol

With hydrogen; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1021/jo01272a005

upstream raw materials:

2-cyclohexylpropanoic acid

2-(Cyclohexen-⁽¹⁾-yl)-propen-⁽²⁾-saeureamid

2-cyclohexylidenepropanoic acid

vinylidenecyclohexane

Downstream raw materials:

(R)-2-cyclohexyl-propionic acid nitrile

Refernces