2-cyclohexylpropan-1-amine

Base Information

• Chemical Name: 2-cyclohexylpropan-1-amine
• CAS No.: 103254-49-5
• Molecular Formula: C₉H₁₉N
• Molecular Weight: 141.257
• Mol file: 103254-49-5.mol

Synonyms:2-cyclohexylpropan-1-amine

Chemical Property of 2-cyclohexylpropan-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-cyclohexylpropan-1-amine

There total 4 articles about 2-cyclohexylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(S)-2-Phenylpropionic acid (7782-24-3) → ethyl-cyclohexane (1678-91-7) + 2-cyclohexylpropanamide (28523-32-2) + 2-cyclohexylpropan-1-amine (103254-49-5)

Guidance literature:

(S)-2-Phenylpropionic acid; With cyclopentyl methyl ether; ammonia; at 200 ℃; under 4500.45 Torr; Sealed tube; Green chemistry;

With cyclopentyl methyl ether; ammonia; hydrogen; at 200 ℃; for 14h; under 42004.2 Torr; Cooling with ice; Green chemistry;

DOI:10.1039/d0gc01441a

Reference yield:

2-phenylpropylamine (582-22-9) → 2-cyclohexylpropan-1-amine (103254-49-5)

Guidance literature:

With acetic acid; platinum; Hydrogenation;

DOI:10.1021/ja01197a039

Reference yield:

3-cyclohexyl-butyric acid amide → 2-cyclohexylpropan-1-amine (103254-49-5)

Guidance literature:

With sodium hydroxide; bromine; beim anschliessenden Erwaermen mit wss. Natronlauge;

DOI:10.1021/ja01197a039

upstream raw materials:

2-phenylpropylamine

(S)-2-Phenylpropionic acid

Downstream raw materials:

(2-cyclohexyl-propyl)-methyl-amine

Refernces

• 1、 Coeck, Robin,De Vos, Dirk E.. "One-pot reductive amination of carboxylic acids: a sustainable method for primary amine synthesis". supporting information. p. 5105 - 5114. Retrieved 2020/08/25.