582-22-9

Basic information

• Product Name: 2-PHENYLPROPYLAMINE
• Synonyms: RARECHEM AL BW 0191;1-AMINO-2-PHENYLPROPANE;2-PHENYLPROPYLAMINE;2-PHENYLPROPAN-1-AMINE;AKOS 236-27;AKOS BBS-00006774;BETA-METHYLPHENETHYLAMINE;ASISCHEM D19374
• CAS NO: 582-22-9
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.21
• EINECS: 209-479-2
• Product Categories: Fine Chemical
• Mol File: 582-22-9.mol
• Article Data: 44

Chemical Properties

• Melting Point: 116°C (estimate)
• Boiling Point: 80 °C10 mm Hg(lit.)
• Flash Point: 175 °F
• Appearance: colorless liquid
• Density: 0.93 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.197mmHg at 25°C
• Refractive Index: n20/D 1.524(lit.)
• PKA: 9.92±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-PHENYLPROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLPROPYLAMINE(582-22-9)
• EPA Substance Registry System: 2-PHENYLPROPYLAMINE(582-22-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• RTECS: SH9520000
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 582-22-9(Hazardous Substances Data)

Usage

Description

2-Phenylpropylamine, also known as β-Methylphenethylamine, is a positional isomer of amphetamine and is a clear colorless liquid. It is an organic compound that has been widely studied for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
2-Phenylpropylamine is used as a molecular imprinting agent for studying the space-filling models depicting minimized structures for each enantiomer. This application is crucial in the development of new drugs and pharmaceuticals, as it helps in understanding the stereochemistry and interactions of different molecules.
Used in Chemical Research:
As a positional isomer of amphetamine, 2-Phenylpropylamine is used in chemical research to study the effects of structural variations on the properties and reactivity of molecules. This knowledge can be applied to design and synthesize new compounds with specific characteristics and applications.
Used in Chiral Separation Techniques:
2-Phenylpropylamine can be employed in chiral separation techniques, which are essential in the pharmaceutical industry for the purification and isolation of enantiomers. Enantiomers are molecules that are mirror images of each other but have different biological activities. The ability to separate these enantiomers is crucial for the development of effective and safe drugs.

InChI:InChI=1/C9H13N/c1-8(7-10)9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/p+1/t8-/m1/s1

Upstream product

• 5841-70-3 phenyl(formyl)acetonitrile 
• 1823-91-2 1-phenylethyl cyanide 
• 107-11-9 1-amino-2-propene 
• 71-43-2 benzene 
• 75-55-8 2-Methylaziridine 
• 59647-78-8 2-phenylpropanal oxime 
• 65501-08-8 (1-Azido-2-phenyl-propoxy)-trimethyl-silane 
• 109757-73-5 1-nitro-2-phenylpropane 
• 98-83-9 isopropenylbenzene 
• 7446-70-0 aluminium trichloride 
• 64-17-5 ethanol 
• 1125-70-8 2-phenylpropanamide 
• 1823-91-2 (R)-α-methylbenzyl cyanide 
• 100-42-5 styrene 

Downstream Products

• 1219-40-5 nicotinic acid-(2-phenyl-propylamide) 
• 17596-79-1 (2S)-2-phenyl-1-propanamine 
• 582-22-9 (R)-2-phenylpropylamine 
• 7577-82-4 2-(2-phenyl-propyl)-(3at,7at)-hexahydro-4r,7c-epioxido-isoindole-1,3-dione 
• 256381-13-2 2-(4-bromophenyl)propan-1-amine 
• 1150104-64-5 C₂₈H₂₇ClN₂O₃ 
• 1178972-90-1 C₁₉H₂₁N₅O₂ 
• 1180007-70-8 C₁₀H₁₂F₃NO₂S 

Relevant articles and documents

CO2-Assisted asymmetric hydrogenation of prochiral allylamines

A new methodology for the asymmetric hydrogenation of allylamines takes advantage of a reversible reaction between amines and carbon dioxide (CO2) to suppress unwanted side reactions. The effects of various parameters (pressure, time, solvent, and base additives) on the enantioselectivity and conversion of the reaction were studied. The homogeneously-catalyzed asymmetric hydrogenation of 2-arylprop- 2-en-1-amine resulted in complete conversion and up to 82% enantiomeric excess (ee). Added base, if chosen carefully, improves the enantioselectivity and chemoselectivity of the overall reaction.

Iron-Catalyzed Diastereoselective Synthesis of Disubstituted Morpholines via C-O or C-N Bond Formation

The diastereoselective synthesis of 2,6- and 3,5-disubstituted morpholines was achieved from 1,2-amino ethers and 1,2-hydroxy amines substituted by an allylic alcohol using an iron(III) catalyst. The morpholines were obtained either by C-O or C-N bond formation. A plausible mechanism is suggested, involving a thermodynamic equilibrium to explain the formation of the cis diastereoisomer as the major product.

Quinazoline derivatives and its preparation method and application

The invention relates to quinazoline derivatives and its preparation method and application. The quinazoline derivatives with The structural formula, the quinazoline derivative to gefitinib for the positive control, the result shows that compared with the gefitinib has good activity; and lead compound OTS514 compared, equivalent activity, PBK/TOPK inhibitors for further transformation and the discovery of new anti-tumor medicine phenological shopping has higher learning with the reference value. The invention also provides a preparation method of the quinazoline derivatives and the preparation of PBK/TOPK inhibitor and an anticancer drug.