(S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine

Base Information

• Chemical Name: (S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine
• CAS No.: 84499-82-1
• Molecular Formula: C₈H₁₅NO₃*C₉H₁₀F₃N
• Molecular Weight: 362.392
• Mol file: 84499-82-1.mol

Synonyms:(S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine

Chemical Property of (S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine

There total 2 articles about (S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

N-Ac-Leu (1188-21-2) + 1-(4-trifluoromethylphenyl)ethylamine (15996-84-6) → (S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine (84499-82-1)

Guidance literature:

In ethanol; water;

DOI:10.1021/ja00344a026

Reference yield:

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → (S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine (84499-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) formic acid, formamide, 2.) 3 N hydrochloric acid / 1.) H₂O, 165-180 deg C, 20 h, 2.) reflux, 48 h

2: 20 percent / ethanol; H₂O

With hydrogenchloride; formic acid; formamide; In ethanol; water;

DOI:10.1021/ja00344a026

Reference yield:

(S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine (84499-82-1) → (S)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine (84499-73-0)

Guidance literature:

DOI:10.1021/ja00344a026

upstream raw materials:

N-Ac-Leu

1-(4-trifluoromethylphenyl)ethylamine

1-(4-trifluoromethylphenyl)ethanone

Downstream raw materials:

(S)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine

Refernces