15996-84-6

Basic information

• Product Name: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE
• Synonyms: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(RS)-1-[4-(Trifluoromethyl)phenyl]ethylamine 98%;BenzeneMethanaMine, a-Methyl-4-(trifluoroMethyl)-;1-[4-(Trifluoromethyl)phenyl]ethylamine, 4-(1-Aminoethyl)benzotrifluoride;alpha-Methyl-4-(trifluoromethyl)benzylamine 98%;alpha-Methyl-4-(trifluoromethyl)benzylamine98%;1-(4-(trifluoromethyl)phenyl)ethan-1-amine
• CAS NO: 15996-84-6
• Molecular Formula: C₉H₁₀F₃N
• Molecular Weight: 189.18
• Mol File: 15996-84-6.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 76.5-77.5
• Flash Point: 82.9°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.271mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.56±0.10(Predicted)
• CAS DataBase Reference: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(15996-84-6)
• EPA Substance Registry System: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(15996-84-6)

Safety Data

• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• Hazardous Substances Data: 15996-84-6(Hazardous Substances Data)

Usage

General Description

(RS)-1-[4-(trifluoromethyl)phenyl]ethylamine is a chemical compound that belongs to the class of organic compounds known as phenylpropylamines. It is a derivative of phenethylamine and contains a trifluoromethyl substituent at the 4-position of the phenyl ring. (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE has potential applications in various fields such as pharmaceuticals, agrochemicals, and materials science. Its chemical structure and properties make it an important building block for the synthesis of complex organic molecules. Additionally, (RS)-1-[4-(trifluoromethyl)phenyl]ethylamine has the potential for use as a pharmaceutical intermediate in the synthesis of drugs and in the development of new therapeutic agents.

InChI:InChI=1/C9H10F3N/c1-6(13)7-2-4-8(5-3-7)9(10,11)12/h2-6H,13H2,1H3

Upstream product

• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 75-31-0 isopropylamine 
• 455-18-5 4-CF₃C₆H₄CN 
• 75-16-1 methylmagnesium bromide 
• 852241-17-9 (1R)-2-oxo-1-phenyl-2-({1-[4-(trifluoromethyl)phenyl]ethyl}amino)ethyl Acetate 
• 15996-83-5 (E)-1-(4-(trifluoromethyl)phenyl)ethan-1-one oxime 
• 107496-43-5 1-(4-(trifluoromethyl)phenyl)ethan-1-one O-methyl oxime 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 15996-83-5 1-[4-(trifluoromethyl)phenyl]ethanone oxime 

Downstream Products

• 84499-82-1 (S)-2-Acetylamino-4-methyl-pentanoic acid; compound with (S)-1-(4-trifluoromethyl-phenyl)-ethylamine 
• 1001413-61-1 C₁₇H₁₆F₃NO₃ 
• 581812-92-2 (R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide 
• 581812-91-1 (S)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide 
• 75-31-0 isopropylamine 
• 15996-83-5 (E)-1-(4-(trifluoromethyl)phenyl)ethan-1-one oxime 

Relevant articles and documents

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.

Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2 H-Isoindoles

We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.

METHOD FOR THE HOMOGENEOUS CATALYTIC REDUCTIVE AMINATION OF CARBONYL COMPOUNDS

The present invention relates to a method for the reductive amination of a carbonyl compound, comprising one or more carbonyl groups amenable to reductive amination, forming the corresponding primary amine, characterized in that the reaction is carried out in the presence of a homogeneously dissolved catalyst complex K, comprising at least one metal atom from Group 8, 9 or 10 of the periodic table, bearing a bidentate phosphane ligand, a carbonyl ligand, a neutral ligand and a hydride ligand, and also an acid as co-catalyst.