dimethyl trimethyl epiblechnate

Base Information

• Chemical Name: dimethyl trimethyl epiblechnate
• CAS No.: 121449-72-7
• Molecular Formula: C₂₃H₂₄O₈
• Molecular Weight: 428.439
• Mol file: 121449-72-7.mol

Synonyms:dimethyl trimethyl epiblechnate

Chemical Property of dimethyl trimethyl epiblechnate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl trimethyl epiblechnate

There total 4 articles about dimethyl trimethyl epiblechnate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2S,3S)-methyl 2-(3,4-dimethoxyphenyl)-4-((E)-3-(((R)-3-(3,4-dimethoxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylate (55757-14-7) + methanol (67-56-1) → dimethyl trimethyl epiblechnate (121449-72-7)

Guidance literature:

With sodium methylate; In chloroform; at 0 - 20 ℃; for 2h;

DOI:10.1021/np060136w

Reference yield:

(2S,3S)-4-[(E)-2-carboxyethenyl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid (136112-75-9) + dimethyl sulfate (77-78-1) → dimethyl trimethyl epiblechnate (121449-72-7)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Reflux;

Reference yield:

dimethyl heptamethyllithospermate B (121521-89-9) → 3-(3,4-dimethoxy-phenyl)-2-hydroxy-propionic acid methyl ester (54814-41-4,54640-00-5,54910-31-5) + dimethyl trimethyl epiblechnate (121449-72-7)

Guidance literature:

With sodium methylate; In methanol; for 5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1248/cpb.37.340

upstream raw materials:

dimethyl heptamethyllithospermate B

(2S,3S)-4-[(E)-2-carboxyethenyl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid

methyl iodide

(2S,3S)-methyl 2-(3,4-dimethoxyphenyl)-4-((E)-3-(((R)-3-(3,4-dimethoxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylate

Refernces

• 1、 -. "Derivatives of 8-epiblechnic Acid and their Effects on Down-Regulation of Endothelin (ETA) receptor mRNA". Page/Page column 3-4. . Retrieved 2010/03/31.
• 2、 Tanaka,Morimoto,Nonaka,Nishioka,Yokozawa,Chung,Oura. "Magnesium and ammonium-potassium lithospermates B, the active principles having a uremia-preventive effect from Salvia miltiorrhiza". . p. 340 - 344. Retrieved 2007/10/02.