2,5-DICHLORO-3,6-DIPHENYL PYRAZINE

Base Information

• Chemical Name: 2,5-DICHLORO-3,6-DIPHENYL PYRAZINE
• CAS No.: 74134-61-5
• Molecular Formula: C₁₆H₁₀Cl₂N₂
• Molecular Weight: 301.175
• Mol file: 74134-61-5.mol

Synonyms:2,5-dichloro-3,6-diphenylpyrazine

Chemical Property of 2,5-DICHLORO-3,6-DIPHENYL PYRAZINE

Chemical Property:

• Melting Point: 159-160 °C
• Boiling Point: 403.9±40.0 °C(Predicted)
• PKA: -5.29±0.10(Predicted)
• Density: 1.307±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-DICHLORO-3,6-DIPHENYL PYRAZINE

There total 7 articles about 2,5-DICHLORO-3,6-DIPHENYL PYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,5-dichloro-3,6-diphenylpyrazine (74134-61-5)

Guidance literature:

With trichlorophosphate; at 180 ℃;

DOI:10.1021/ja01597a057

Reference yield:

phenylglyoxylic acid ethyl ester (1603-79-8) → 2,5-dichloro-3,6-diphenylpyrazine (74134-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / methanol / 3.5 h / 40 °C

2: POCl₃ / Heating

With trichlorophosphate; In methanol;

Reference yield:

Phenylglycinamid (700-63-0) → 2,5-dichloro-3,6-diphenylpyrazine (74134-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / methanol / 3.5 h / 40 °C

2: POCl₃ / Heating

With trichlorophosphate; In methanol;

upstream raw materials:

3,6-diphenyl-piperazine-2,5-dione

2-(2-Oxo-2-phenyl-acetylamino)-2-phenyl-acetamide

trichlorophosphate

phenylglyoxylic acid ethyl ester

Downstream raw materials:

4-chloro-1-cyano-2,5-diphenylimidazole

4-chloro-2,5-diphenylimidazole

2,5-dihydroxy-3,6-diphenylpyrazine

2-Azido-5-chloro-3,6-diphenylpyrazine

Refernces