Technology Process of 5-([1,2,4]triazolo[1,5-α]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline
There total 7 articles about 5-([1,2,4]triazolo[1,5-α]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3-([1,2,4]triazolo[1,5-a;]pyridin-6-yl)benzylamino)-1-(3,4-dichlorophenyl)ethanol;
With
sulfuric acid;
In
dichloromethane;
at 0 - 20 ℃;
With
ammonium hydroxide;
In
water; ethyl acetate;
pH=10;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic anhydride / tetrahydrofuran / 2 h / 10 - 20 °C
2.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 0.25 h / 45 °C
3.1: methanol; dichloromethane / 2 h / 20 °C
3.2: 0.17 h
4.1: sulfuric acid / dichloromethane / 0 - 20 °C
With
sulfuric acid; caesium carbonate; trifluoroacetic anhydride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
2.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 0.25 h / 45 °C
2.1: methanol; dichloromethane / 2 h / 20 °C
2.2: 0.17 h
3.1: sulfuric acid / dichloromethane / 0 - 20 °C
With
sulfuric acid; caesium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; dichloromethane; water; dimethyl sulfoxide;
1.1: Suzuki Coupling;