4-bromobutyric acid 4'-acetylaminophenyl ester

Base Information

• Chemical Name: 4-bromobutyric acid 4'-acetylaminophenyl ester
• CAS No.: 410071-27-1
• Molecular Formula: C₁₂H₁₄BrNO₃
• Molecular Weight: 300.152
• Mol file: 410071-27-1.mol

Synonyms:4-bromobutyric acid 4'-acetylaminophenyl ester

Chemical Property of 4-bromobutyric acid 4'-acetylaminophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-bromobutyric acid 4'-acetylaminophenyl ester

There total 2 articles about 4-bromobutyric acid 4'-acetylaminophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-bromobutyroyl chloride (927-58-2) + 4-acetaminophenol (103-90-2,8055-08-1) → 4-bromobutyric acid 4'-acetylaminophenyl ester (410071-27-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

bromobutyric acid (2623-87-2) + 4-acetaminophenol (103-90-2,8055-08-1) → 4-bromobutyric acid 4'-acetylaminophenyl ester (410071-27-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In DMF (N,N-dimethyl-formamide); chloroform; at 20 ℃; for 72h;

Reference yield: 40.0%

formic acid (64-18-6) + (S)-cyclohexyl-(5-dimethylaminomethyl-oxazol-2-yl)-phenyl-methanol + 4-bromobutyric acid 4'-acetylaminophenyl ester (410071-27-1) → [3-(4-acetylaminophenoxycarbonyl)propyl]-[2-((R)-cyclohexylhydroxyphenylmethyl)oxazol-5-ylmethyl]dimethylammonium formate (1046769-01-0)

Guidance literature:

(S)-cyclohexyl-(5-dimethylaminomethyl-oxazol-2-yl)-phenyl-methanol; 4-bromobutyric acid 4'-acetylaminophenyl ester; In chloroform; acetonitrile; at 50 ℃; for 16h;

formic acid; In water; acetonitrile;

upstream raw materials:

bromobutyric acid

4-acetaminophenol

4-bromobutyroyl chloride

Downstream raw materials:

[3-(4-acetylaminophenoxycarbonyl)propyl]-[2-((R)-cyclohexylhydroxyphenylmethyl)oxazol-5-ylmethyl]dimethylammonium formate

Refernces

• 1、 -. "OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES 2". Page/Page column 47. . Retrieved 2008/12/08.