ethyl 2,3-dibromo-3-phenylpropanoate

Base Information

• Chemical Name: ethyl 2,3-dibromo-3-phenylpropanoate
• CAS No.: 99570-23-7
• Molecular Formula: C₁₁H₁₂Br₂O₂
• Molecular Weight: 336.023
• Mol file: 99570-23-7.mol

Synonyms:ethyl 2,3-dibromo-3-phenylpropanoate

Chemical Property of ethyl 2,3-dibromo-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2,3-dibromo-3-phenylpropanoate

There total 12 articles about ethyl 2,3-dibromo-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl cinnamate (4192-77-2) → rac-(2S,3R)-ethyl 2,3-dibromo-3-phenylpropanoate (5464-70-0,30983-70-1,87439-83-6,99107-37-6,99570-22-6,99570-23-7,100227-07-4)

Guidance literature:

With oxone||potassium monopersulfate triple salt; potassium bromide; N-(n-butyl)-2-methylbenzamide; In dichloromethane; water; at 20 ℃; for 1h; Reagent/catalyst; diastereoselective reaction;

DOI:10.1039/c3cc49850f

Reference yield: 91.0%

ethyl cinnamate (4192-77-2) → 2,3-Dibromo-3-phenyl-propionic acid ethyl ester (5464-70-0,30983-70-1,87439-83-6,99107-37-6,99570-22-6,99570-23-7,100227-07-4)

Guidance literature:

With maghemite(γ-Fe₂O₃) nanoparticle supported 2,2'-bis[3-(triethoxysilyl)propyl]imidazolium substituted diethyl ether bis(tribromide); In methanol; dichloromethane; for 6h; Reflux;

DOI:10.1002/ejic.201300755

Reference yield: 88.0%

ethyl 3-phenyl-2-propenoate (103-36-6) → rac-(2S,3R)-ethyl 2,3-dibromo-3-phenylpropanoate (5464-70-0,30983-70-1,87439-83-6,99107-37-6,99570-22-6,99570-23-7,100227-07-4)

Guidance literature:

With Oxalyl bromide; Triphenylphosphine oxide; In 1,2-dichloro-ethane; at 40 ℃; for 36h; diastereoselective reaction; Molecular sieve; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4cc02847c

upstream raw materials:

ethyl cinnamate

N-bromoacetamide

(Z)-ethyl cinnamate

ethyl 3-phenyl-2-propenoate

Downstream raw materials:

(Z)-ethyl 2-bromo-3-phenylprop-2-enoate

(E)-ethyl 2-bromo-3-phenylpropenoate

[(E)-2-bromoethenyl]benzene

ethyl 2-bromo-3-phenylacrylate

Refernces

• 1、 -. "Preparation method of 1-aryl-1,2-dibromoethane". Paragraph 0023-0024. . Retrieved 2020/03/16.
• 2、 Stodulski, Maciej,Goetzinger, Alissa,Kohlhepp, Stefanie V.,Gulder, Tanja. "Halocarbocyclization versus dihalogenation: Substituent directed iodine(iii) catalyzed halogenations". supporting information. p. 3435 - 3438. Retrieved 2014/03/21.