6-fluoro-2-phenylquinazoline

Base Information

• Chemical Name: 6-fluoro-2-phenylquinazoline
• CAS No.: 1399327-71-9
• Molecular Formula: C₁₄H₉FN₂
• Molecular Weight: 224.237
• Mol file: 1399327-71-9.mol

Synonyms:6-fluoro-2-phenylquinazoline

Chemical Property of 6-fluoro-2-phenylquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-fluoro-2-phenylquinazoline

There total 14 articles about 6-fluoro-2-phenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

benzaldehyde (100-52-7) + (2-amino-5-fluorophenyl)methanol (748805-85-8) → 6-fluoro-2-phenylquinazoline (1399327-71-9)

Guidance literature:

With [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cerium(III) nitrate hexahydrate; oxygen; ammonium chloride; copper(l) chloride; potassium hydroxide; In acetonitrile; at 30 - 80 ℃; for 48h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/jo401908g

Reference yield: 85.0%

6-fluoro-2-phenyl-3,4-dihydroquinazoline → 6-fluoro-2-phenylquinazoline (1399327-71-9)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1021/jacs.7b03131

Reference yield: 82.0%

C8H7FN2O3 + benzyl alcohol (100-51-6,185532-71-2) → 6-fluoro-2-phenylquinazoline (1399327-71-9)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; at 160 ℃; for 48h; Inert atmosphere;

DOI:10.1039/c4ob01296h

upstream raw materials:

benzamidine monohydrochloride

2-bromo-5-fluorobenzyl bromide

benzaldehyde

(2-amino-5-fluorophenyl)methanol

Refernces

• 1、 Ma, Jin-Tian,Wang, Li-Sheng,Chai, Zhi,Chen, Xin-Feng,Tang, Bo-Cheng,Chen, Xiang-Long,He, Cai,Wu, Yan-Dong,Wu, An-Xin. "Access to 2-arylquinazolinesviacatabolism/reconstruction of amino acids with the insertion of dimethyl sulfoxide". supporting information. p. 5414 - 5417. Retrieved 2021/06/09.
• 2、 Chatterjee, Tanmay,Kim, Dong In,Cho, Eun Jin. "Base-Promoted Synthesis of 2-Aryl Quinazolines from 2-Aminobenzylamines in Water". . p. 7423 - 7430. Retrieved 2018/07/29.