methyl 2-bromo-2-fluoroacetate

Base Information

• Chemical Name: methyl 2-bromo-2-fluoroacetate
• CAS No.: 684-89-9
• Molecular Formula: C₃H₄BrFO₂
• Molecular Weight: 170.966
• Mol file: 684-89-9.mol

Synonyms:methyl 2-bromo-2-fluoroacetate

Chemical Property of methyl 2-bromo-2-fluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-bromo-2-fluoroacetate

There total 2 articles about methyl 2-bromo-2-fluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E/Z)-1,2-dibromo-1,2-difluoroethylene (359-21-7) + sodium methylate (124-41-4) → Methyl dimethoxyacetate (89-91-8) + methyl 2-bromo-2-fluoroacetate (684-89-9)

Guidance literature:

In methanol; at 75 - 80 ℃; for 40h; Product distribution;

DOI:10.1021/jo00064a036

Reference yield:

(E/Z)-1,2-dibromo-1,2-difluoroethylene (359-21-7) + sodium methylate (124-41-4) → Methyl dimethoxyacetate (89-91-8) + methyl 2-bromo-2-fluoroacetate (684-89-9) + bromo-2-trifluoro-1,1,2-ethyl-methyl ether (679-90-3) + 1,1-difluoro-1,2,2-trimethoxyethane + (E)-1-Bromo-1,2-difluoro-2-methoxy-ethene + (Z)-1-Bromo-1,2-difluoro-2-methoxy-ethene

Guidance literature:

In methanol; at 70 - 80 ℃; for 8h; Product distribution;

DOI:10.1021/jo00064a036

Reference yield: 88.01%

methyl 2-bromo-2-fluoroacetate (684-89-9) → fluorobromoethanol (459424-41-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h;

upstream raw materials:

(E/Z)-1,2-dibromo-1,2-difluoroethylene

sodium methylate

Downstream raw materials:

diphenyl-phosphinoxy-fluoroacetate de methyle

fluorobromoethanol

Refernces