2,2-Bis(4-methoxyphenyl)ethylamine

Base Information

• Chemical Name: 2,2-Bis(4-methoxyphenyl)ethylamine
• CAS No.: 85336-83-0
• Molecular Formula: C16H19NO2
• Molecular Weight: 257.33
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID30426835
• Wikidata: Q82239635
• ChEMBL ID: CHEMBL275567
• Mol file: 85336-83-0.mol

Synonyms:2,2-BIS(4-METHOXYPHENYL)ETHYLAMINE;85336-83-0;2,2-bis(4-methoxyphenyl)ethanamine;CHEMBL275567;SCHEMBL2086794;DTXSID30426835;AKOS015851860;2,2-BIS(4-METHOXYLPHENYL)ETHYLAMINE

Chemical Property of 2,2-Bis(4-methoxyphenyl)ethylamine

Chemical Property:

• Vapor Pressure: 1.08E-06mmHg at 25°C
• Melting Point: 45-50 °C
• Refractive Index: 1.561
• Boiling Point: 402.7 °C at 760 mmHg
• Flash Point: 217.7 °C
• PSA: 44.48000
• Density: 1.082 g/cm³
• LogP: 3.49470
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 257.141578849
• Heavy Atom Count: 19
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

2,2-Bis(4-methoxyphenyl)ethylamine, 98% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37-38

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CN)C2=CC=C(C=C2)OC

Technology Process of 2,2-Bis(4-methoxyphenyl)ethylamine

There total 9 articles about 2,2-Bis(4-methoxyphenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-Dimethoxybenzhydrol (728-87-0) → 2,2-bis(p-methoxyphenyl)ethylamine (85336-83-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 20 °C

2: titanium tetrachloride / dichloromethane / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / diethyl ether / 24 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; titanium tetrachloride; In diethyl ether; dichloromethane;

DOI:10.3390/molecules25153488

Reference yield:

4-methoxyphenyl magnesium bromide (13139-86-1) → 2,2-bis(p-methoxyphenyl)ethylamine (85336-83-0)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 24 h / 0 - 20 °C

2: thionyl chloride / dichloromethane / 20 °C

3: titanium tetrachloride / dichloromethane / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / diethyl ether / 24 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; titanium tetrachloride; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.3390/molecules25153488

Reference yield:

4,4'-dimethoxydiphenylmethyl chloride (7525-23-7) → 2,2-bis(p-methoxyphenyl)ethylamine (85336-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium tetrachloride / dichloromethane / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 24 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; titanium tetrachloride; In diethyl ether; dichloromethane;

DOI:10.3390/molecules25153488

upstream raw materials:

2,2-bis-(p-methoxyphenyl)-1-nitroethylene

bis-3,3-(p-methoxyphenyl)-propionic acid

4,4'-(2-nitroethane-1,1-diyl)bis(methoxybenzene)

methoxybenzene

Downstream raw materials:

7-methoxy-4-(4-methoxy-phenyl)-isoquinoline

7-methoxy-4-(4-methoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline

Refernces