AMINOPOLYETHYLENE GLYCOL 5'000 MONOMETHYL ETHER

Base Information

• Chemical Name: AMINOPOLYETHYLENE GLYCOL 5'000 MONOMETHYL ETHER
• CAS No.: 80506-64-5
• Molecular Formula: C₉H₂₁NO₄
• Molecular Weight: 207.27
• Hs Code.: 39072090
• Mol file: 80506-64-5.mol

Synonyms:MPEG-NH2;Poly(ethylene glycol)2-aminoethyl methyl ether;Polyethylene glycol mono(2-aminoethyl) monomethylether;a-Amino-w-methoxypolyethylene glycol;a-Methoxy-w-aminopoly(ethylene glycol);

Chemical Property of AMINOPOLYETHYLENE GLYCOL 5'000 MONOMETHYL ETHER

Chemical Property:

• Melting Point: 58-61 °C(lit.)
• Flash Point: >110℃
• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: −20°C
• Solubility.: Chloroform (Slightly), MEtanol (Slightly)
• Water Solubility.: Soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

MPEG-NH2(Mn=2,000) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG15-amine is a PEG linker containing an amino group and 15 PEG units. It is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.
• Uses: MPEG-NH2 is a reactant in synthesis of pH-sensitive polymeric micelles for intracellular drug delivery. PEG functionalized with amine for ligation and coupling reactions. Methoxypolyethylene glycol amine is generally used for the chemical modification of biologically active compounds and therapeutic agents. It has been used to increase the aqueous solubility of long-wavelength voltage-sensitive dyes and to prepare the PEG-coated fluorescent beads in studying large-scale rotational cytoplasmic flow.

Technology Process of AMINOPOLYETHYLENE GLYCOL 5'000 MONOMETHYL ETHER

There total 58 articles about AMINOPOLYETHYLENE GLYCOL 5'000 MONOMETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-(2-methoxyethoxy)ethoxy)ethyl azide (74654-06-1,89485-61-0) → 2-[2-(2-methoxyethoxy)ethoxy]ethylamine (74654-07-2,80506-64-5,869718-87-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 98.0%

1-azido-2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane (1043884-49-6,89485-61-0) → 3,6,9,12-tetraoxa-tridecylamine (85030-56-4,80506-64-5,869718-87-6)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.3390/molecules200916085

Reference yield: 97.0%

1-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-2-methoxyethane (606130-90-9,89485-61-0) → 3,6,9,12-tetraoxa-tridecylamine (85030-56-4,80506-64-5,869718-87-6)

Guidance literature:

1-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-2-methoxyethane; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;

With water; In tetrahydrofuran; for 24h;

DOI:10.1021/ja035558w

upstream raw materials:

16-azido-2,5,8,11,14-pentaoxahexadecane

3,6,9,12,15-pentaoxahexadecanol

3,6,9,12,15-pentaoxahexadecyl tosylate

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

Downstream raw materials:

C₁₉H₃₂N₂O₁₀

Refernces

• 1、 Kobayakawa, Takuya,Tsuji, Kohei,Konno, Kiju,Himeno, Ai,Masuda, Ami,Yang, Tingting,Takahashi, Kohei,Ishida, Yusuke,Ohashi, Nami,Kuwata, Takeo,Matsumoto, Kaho,Yoshimura, Kazuhisa,Sakawaki, Hiromi,Miura, Tomoyuki,Harada, Shigeyoshi,Matsushita, Shuzo,Tamamura, Hirokazu. "Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors". . p. 1481 - 1496. Retrieved 2021/02/27.
• 2、 Pineux, Florent,Federico, Stephanie,Klotz, Karl-Norbert,Kachler, Sonja,Michiels, Carine,Sturlese, Mattia,Prato, Maurizio,Spalluto, Giampiero,Moro, Stefano,Bonifazi, Davide. "Targeting G Protein-Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor". supporting information. p. 1909 - 1920. Retrieved 2020/09/11.