2,4,6-TRIFLUOROPHENYLHYDRAZINE

Base Information

• Chemical Name: 2,4,6-TRIFLUOROPHENYLHYDRAZINE
• CAS No.: 80025-72-5
• Molecular Formula: C6H5 F3 N2
• Molecular Weight: 162.114
• Hs Code.: 2928000090
• Mol file: 80025-72-5.mol

Synonyms:2,4,6-Trifluorophenylhydrazine

Chemical Property of 2,4,6-TRIFLUOROPHENYLHYDRAZINE

Chemical Property:

• Vapor Pressure: 5.59mmHg at 25°C
• Melting Point: 97-99°C
• Refractive Index: 1.552
• Boiling Point: 142.4°C at 760 mmHg
• PKA: 4.31±0.33(Predicted)
• Flash Point: 39.9°C
• PSA: 38.05000
• Density: 1.491g/cm³
• LogP: 2.16280
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2,4,6-Trifluorophenylhydrazine 97.0% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Propionic acid (2,4,6-trichlorophenyl)hydrazide was prepared by reaction of (2,4,6-trichlorophenyl)- hydrazine with propionyl chloride in pyridine. Visnaginone Ia reacted with phenyl hydrazine and 2,4,6- trichlorophenyl hydrazine to yield the corresponding hydrazones.

Technology Process of 2,4,6-TRIFLUOROPHENYLHYDRAZINE

There total 2 articles about 2,4,6-TRIFLUOROPHENYLHYDRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-trifluoroaniline (363-81-5) → (2,4,6-trifluorophenyl)hydrazine (80025-72-5)

Guidance literature:

In 2,3,4,6-tetrafluoroaniline;

Reference yield:

→ (2,4,6-trifluorophenyl)hydrazine (80025-72-5)

Guidance literature:

1,4-Dihydrazino-tetrafluor-benzol, wss.3N-NaOH, 4h Kochen (neben 56percent 2,3,5,6-Tetrafluor-anilin);

DOI:10.1021/jo01033a061

Reference yield: 67.0%

tert-butyl (7-chloro-2,8-dioxo-1-oxaspiro[4.5]deca-6,9-dien-3-yl)carbamate + (2,4,6-trifluorophenyl)hydrazine (80025-72-5) → (S,E)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-((2,4,6-trifluorophenyl)diazenyl)phenyl) propanoic acid

Guidance literature:

With ammonium cerium (IV) nitrate; In acetonitrile; at 20 ℃; for 48h;

DOI:10.1021/acs.orglett.5b03268

upstream raw materials:

2,4,6-trifluoroaniline

Downstream raw materials:

4-iodo-1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridine

(E)-2-fluoro-4-iodo-3-((2-(2,4,6-trifluorophenyl)hydrazono)methyl)pyridine

1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid

Refernces

• 1、 -. "N-Phenylpyrazole derivatives". . . Retrieved 2008/06/13.