Technology Process of N-(3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)acetamide
There total 4 articles about N-(3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 4-(4-(6-acetamido-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate;
With
hydrogenchloride;
In
1,4-dioxane; ethyl acetate;
at 20 ℃;
With
sodium hydrogencarbonate;
In
1,4-dioxane; water; ethyl acetate;
pH=8;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 100 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 20 °C
3.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 20 °C
3.2: pH 8
With
pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate;
In
1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C
5.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 100 °C / Inert atmosphere
6.1: pyridine / dichloromethane / 20 °C
7.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 20 °C
7.2: pH 8
With
pyridine; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; lithium aluminium tetrahydride; iron; sodium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
