4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE
• CAS No.: 84449-81-0
• Molecular Formula: C₃H₃NO₂
• Molecular Weight: 85.0623
• Mol file: 84449-81-0.mol

Synonyms:Benzoylchloride, 4-[2-(1-piperidinyl)ethoxy]-, hydrochloride (9CI); 4-(2-Piperidinoethoxy)benzoylchloride hydrochloride

Chemical Property of 4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE

Chemical Property:

• PSA: 29.54000
• LogP: 3.67020

Purity/Quality:

98%Min ^*data from raw suppliers

4-(2-Piperidinoethoxy)benzoylChlorideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(2-Piperidinoethoxy)benzoyl Chloride Hydrochloride is a reactant used in the preparation of highly potent revertants of P-glycoprotein-associated MDR.

Technology Process of 4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE

There total 27 articles about 4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,2,4,5-tetrazine-3,6-dicarboxylic acid dimethyl ester (2166-14-5) + 2,2-dimethylpropylidynephosphine (78129-68-7) → methyl cyanoformate (17640-15-2) + 4-tert-Butyl-1-(2,4,5-tri-tert-butyl-[1,3]diphosphol-1-yl)-1H-[1,2,3]azadiphosphole-5-carboxylic acid methyl ester (122747-89-1)

Guidance literature:

In toluene; at 110 ℃; for 24h; sealed tube;

DOI:10.1016/S0040-4039(00)82211-X

Reference yield: 55.0%

methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl cyanoformate (17640-15-2) + triphenylphosphine oxide-nitric acid complex (18365-29-2)

Guidance literature:

With Nitrogen dioxide; In dichloromethane; Yields of byproduct given; Ambient temperature;

DOI:10.1002/(SICI)1099-0690(199901)1999:1<251::AID-EJOC251>3.0.CO;2-M

Reference yield:

potassium cyanide (151-50-8) + methyl chloroformate (79-22-1) → methyl cyanoformate (17640-15-2)

Guidance literature:

With 18-crown-6 ether; In dichloromethane;

DOI:10.1021/jo00883a041

upstream raw materials:

2-methoxyacetonitrile

methyl 2-amino-2-oxoacetate

sodium cyanide

methyl chloroformate

Refernces

• 1、 Sugimoto, Hiromichi,Nakamura, Satoshi,Ohwada, Tomohiko. "Retro-Diels-Alder reaction of 4H-1,2-benzoxazines to generate o-quinone methides: Involvement of highly polarized transition states". . p. 10088 - 10095. Retrieved 2008/04/12.
• 2、 -. "Process for producing cyanoformate esters". . . Retrieved 2008/06/13.