4,8-DICHLORO-2-METHYLQUINOLINE

Base Information

• Chemical Name: 4,8-DICHLORO-2-METHYLQUINOLINE
• CAS No.: 75896-69-4
• Molecular Formula: C₁₀H₇Cl₂N
• Molecular Weight: 212.078
• Hs Code.: 2933499090
• Mol file: 75896-69-4.mol

Synonyms:Quinaldine,4,8-dichloro- (7CI); 4,8-Dichloro-2-methylquinoline

Chemical Property of 4,8-DICHLORO-2-METHYLQUINOLINE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.644
• Boiling Point: 301.315°C at 760 mmHg
• Flash Point: 164.425°C
• PSA: 12.89000
• Density: 1.351g/cm³
• LogP: 3.85000

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,8-Dichloro-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,8-DICHLORO-2-METHYLQUINOLINE

There total 7 articles about 4,8-DICHLORO-2-METHYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-chloro-2-methyl-quinolin-4-ol (5236-87-3) → 4,8-dichloro-2-methylquinoline (75896-69-4)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ja01262a053

Reference yield:

3-(2-chloro-anilino)-trans-crotonic acid ethyl ester (42792-92-7) → 4,8-dichloro-2-methylquinoline (75896-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: paraffin oil / 240 °C

2: phosphoryl chloride

With paraffin oil; trichlorophosphate;

DOI:10.1021/ja01262a053

Reference yield:

o-chloroaniline (95-51-2) → 4,8-dichloro-2-methylquinoline (75896-69-4)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous hydrochloric acid

2: paraffin oil / 240 °C

3: phosphoryl chloride

With hydrogenchloride; paraffin oil; trichlorophosphate;

DOI:10.1021/ja01262a053

upstream raw materials:

4-chloro-2-methylquinolin-8-amine

8-chloro-2-methyl-quinolin-4-ol

4-chloro-2-methyl-8-nitroquinoline

3-(2-chloro-anilino)-trans-crotonic acid ethyl ester

Downstream raw materials:

4-[(2-aminophenyl)thio]-2-methyl-8-chloroquinoline hydrochloride