4-Chloro-2-methyl-8-nitroquinoline

Base Information

• Chemical Name: 4-Chloro-2-methyl-8-nitroquinoline
• CAS No.: 56983-07-4
• Molecular Formula: C₁₀H₇ClN₂O₂
• Molecular Weight: 222.631
• European Community (EC) Number: 842-643-7
• Mol file: 56983-07-4.mol

Synonyms:4-chloro-2-methyl-8-nitroquinoline;56983-07-4;SCHEMBL9069976;VJQVEHIJBHZXEV-UHFFFAOYSA-N;AKOS002662919;CS-0227398;EN300-126788

Chemical Property of 4-Chloro-2-methyl-8-nitroquinoline

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 222.0196052
• Heavy Atom Count: 15
• Complexity: 256

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C2C=CC=C(C2=N1)[N+](=O)[O-])Cl

Technology Process of 4-Chloro-2-methyl-8-nitroquinoline

There total 1 articles about 4-Chloro-2-methyl-8-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-methylquinoline (4295-06-1) → 4-chloro-2-methyl-5-nitroquinoline (145363-63-9) + 4-chloro-2-methyl-8-nitroquinoline (56983-07-4) + 4-chloro-2-methyl-7-nitro-quinoline (56983-09-6)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; Overall yield = 80 %;

DOI:10.1007/s10593-013-1380-4

Reference yield: 95.0%

4-chloro-2-methyl-8-nitroquinoline (56983-07-4) → 4-chloro-2-methylquinolin-8-amine (127171-93-1)

Guidance literature:

With ethanol; acetic acid; for 4h; Reflux;

DOI:10.1002/cmdc.201700734

Reference yield:

4-chloro-2-methyl-8-nitroquinoline (56983-07-4) → N-(4-methoxy-2-methyl-8-quinolyl)-(4-methylbenzene)sulfonamide

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / Na / 2 h / Heating

2: 96 percent / Fe; AcOH / ethanol / 4 h / Heating

3: 90 percent / pyridine / CH₂Cl₂

With pyridine; sodium; iron; acetic acid; In ethanol; dichloromethane;

DOI:10.1071/CH01071

upstream raw materials:

4-chloro-2-methylquinoline

Downstream raw materials:

4-chloro-2-methylquinolin-8-amine

4,8-dichloro-2-methylquinoline

Refernces