Multi-step reaction with 9 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 °C
2.1: triethylamine; 1,4-dithio-erythritol / dichloromethane / 1.5 h / 20 °C
3.1: sodium hydroxide / tert-butyl alcohol / 20 °C
3.2: 15 h / 20 °C
4.1: dmap; pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 - 50 °C
6.1: hydrogen / palladium(II) hydroxide / ethanol / 16 h / 20 °C / 760.05 Torr / Inert atmosphere
7.1: pyridine / dichloromethane / 2.08 h / 0 - 20 °C
8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
9.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 2 h / 20 °C
With
pyridine; dmap; sodium azide; 1,4-dithio-erythritol; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
palladium(II) hydroxide;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;