(1-Aminocyclopropyl)methanol hydrochloride

Base Information

• Chemical Name: (1-Aminocyclopropyl)methanol hydrochloride
• CAS No.: 115652-52-3
• Molecular Formula: C4H9NO^.HCl
• Molecular Weight: 123.582
• Hs Code.: 2922199090
• European Community (EC) Number: 808-869-5
• DSSTox Substance ID: DTXSID30556560
• Mol file: 115652-52-3.mol

Synonyms:115652-52-3;(1-aminocyclopropyl)methanol hydrochloride;1-Aminocyclopropanemethanol hydrochloride;1-Amino-1-(hydroxymethyl)cyclopropane hydrochloride;(1-amino-cyclopropyl)-methanol hydrochloride;(1-AMINOCYCLOPROPYL)METHANOL HCL;Cyclopropanemethanol, 1-amino-, hydrochloride (1:1);(1-aminocyclopropyl)methanol;hydrochloride;1-Amino-cyclopropanemethanol hydrochloride;1-Amino-cyclopropanemethanol, HCl;MFCD09834330;1-aminocyclopropanemethanol HCl;Cyclopropanemethanol, 1-amino-, hydrochloride;1-amino-1-cyclopropanemethanol hydrochloride;SCHEMBL365342;DTXSID30556560;ULEMJGCUGKDKTD-UHFFFAOYSA-N;1-Aminocyclopropane-1-methanol HCl;CS-D0148;AKOS015847707;AM81133;GS-4138;SB20291;AC-22289;SY017513;(1-aminocyclopropyl) methanol hydrochloride;(aminocyclopropyl)methan-1-ol hydrochloride;EN300-117059;(1-Aminocyclopropyl) methanol hydrochloride, 98%;J-504175;(1-Amino-cyclopropyl)-methanol hydrochloride, AldrichCPR;(1-Aminocyclopropyl)methanol--hydrogen chloride (1/1);Z1741975623

Chemical Property of (1-Aminocyclopropyl)methanol hydrochloride

Chemical Property:

• Melting Point: 119 oC (DEC.)
• Boiling Point: 188.2 °C at 760 mmHg
• Flash Point: 67.6 °C
• PSA: 46.25000
• LogP: 0.97230
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.0450916
• Heavy Atom Count: 7
• Complexity: 58.6

Purity/Quality:

99.9% ^*data from raw suppliers

1-Amino-cyclopropanemethanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1(CO)N.Cl

Technology Process of (1-Aminocyclopropyl)methanol hydrochloride

There total 2 articles about (1-Aminocyclopropyl)methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(benzyloxymethyl)-1-(dibenzylamino)cyclopropane (308266-11-7) → 1-amino-1-(hydroxymethyl)cyclopropane hydrochloride (115652-52-3) + 1-benzyloxymethyl-cyclopropylamine; hydrochloride

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 72h; under 750.06 Torr;

DOI:10.1002/1099-0690(200009)2000:18<3235::aid-ejoc3235>3.0.co;2-7

Reference yield:

tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate (107017-73-2) → 1-amino-1-(hydroxymethyl)cyclopropane hydrochloride (115652-52-3)

Guidance literature:

With hydrogenchloride; In dichloromethane; for 3h; Yield given; Ambient temperature;

DOI:10.1021/jm00118a026

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-amino-1-(hydroxymethyl)cyclopropane hydrochloride (115652-52-3) → tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate (107017-73-2)

Guidance literature:

1-amino-1-(hydroxymethyl)cyclopropane hydrochloride; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 0 - 20 ℃;

upstream raw materials:

tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate

1-(benzyloxymethyl)-1-(dibenzylamino)cyclopropane

Downstream raw materials:

[1-(3,5-dichlorophenylamino)cyclopropyl]methanol

benzyl (R)-3-((R)-2,3-didodecanamidopropylthio)-1-(1-(hydroxymethyl)cyclopropylamino)-1-oxopropan-2-ylcarbamate

1-(N-benzylamino)-1-cyclopropanemethanol

tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate

Refernces

• 1、 -. "Heterocyclic compound serving as SOS1 inhibitor". Paragraph 0151-0153. . Retrieved 2021/08/06.
• 2、 -. "SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES". Page/Page column 59. . Retrieved 2011/02/18.