Di-t-butyl(2,2-diphenyl-1-methylcyclopropyl)phosphinecBRIDP

Base Information

• Chemical Name: Di-t-butyl(2,2-diphenyl-1-methylcyclopropyl)phosphinecBRIDP
• CAS No.: 742103-27-1
• Molecular Formula: C24H33 P
• Molecular Weight: 352.5
• Hs Code.: 2931499090
• Mol file: 742103-27-1.mol

Synonyms:Di-t-butyl(2,2-diphenyl-1-methylcyclopropyl)phosphinecBRIDP

Chemical Property of Di-t-butyl(2,2-diphenyl-1-methylcyclopropyl)phosphinecBRIDP

Chemical Property:

• Melting Point: 87-91°C
• Boiling Point: 427.3±45.0 °C(Predicted)
• PSA: 13.59000
• LogP: 7.21400
• Sensitive.: air sensitive, store cold

Purity/Quality:

98%,99%, ^*data from raw suppliers

cBRIDP(regR) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ligand for greener Buchwald-Hartwig coupling in TPGS-750-M.

Technology Process of Di-t-butyl(2,2-diphenyl-1-methylcyclopropyl)phosphinecBRIDP

There total 2 articles about Di-t-butyl(2,2-diphenyl-1-methylcyclopropyl)phosphinecBRIDP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 1-chloro-1-methyl-2,2-diphenylcyclopropane (74972-62-6) → ?di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine (742103-27-1)

Guidance literature:

1-chloro-1-methyl-2,2-diphenylcyclopropane; With tert-butylmagnesium chloride; iodine; magnesium; In tetrahydrofuran; at 65 ℃; Inert atmosphere;

di(tert-butyl)chlorophosphine; With copper(l) iodide; lithium bromide; In tetrahydrofuran; at 55 ℃; for 6h; Inert atmosphere;

DOI:10.1002/adsc.200700543

Reference yield: 47.0%

di(tert-butyl)chlorophosphine (13716-10-4) + 1-bromo-1-methyl-2,2-diphenylcyclopropane (27468-37-7) → ?di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine (742103-27-1)

Guidance literature:

1-bromo-1-methyl-2,2-diphenylcyclopropane; With magnesium; iodine; In tetrahydrofuran; at 40 ℃; for 1h;

di(tert-butyl)chlorophosphine; With copper(l) iodide; lithium bromide; In tetrahydrofuran; at 60 ℃; for 3h; Product distribution / selectivity;

Reference yield: 97.0%

?di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine (742103-27-1) + bis(η3-allyl-μ-chloropalladium(II)) → PdCl(π-allyl)(cyclohexyl-(1-methyl-2,2-diphenylcyclopropylphophine)) (742103-28-2)

Guidance literature:

In toluene; at 30 ℃; for 2h; Inert atmosphere;

DOI:10.1002/adsc.201300332

upstream raw materials:

di(tert-butyl)chlorophosphine

1-chloro-1-methyl-2,2-diphenylcyclopropane

1-bromo-1-methyl-2,2-diphenylcyclopropane

Downstream raw materials:

3-chloro-1-phenyl-1H-indazole

N-(1-phenyl-1H-indazole-3-yl)aniline

N-(1-phenyl-1H-indazole-3-yl)-N-(6-phenylpyridine-2-yl)aniline

N-(1-phenylpyrazole-3-yl)-4-t-butylaniline

Refernces

• 1、 -. "PHOSPHINE COMPOUND, INTERMEDIATE, PALLADIUM-COMPLEX, AND USE THEREOF". Page/Page column 46-47. . Retrieved 2010/02/08.