2-ACETYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

Base Information

• Chemical Name: 2-ACETYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
• CAS No.: 741709-58-0
• Molecular Formula: C₁₃H₁₈BNO₃
• Molecular Weight: 247.102
• Hs Code.: 2934999090
• Mol file: 741709-58-0.mol

Synonyms:2-Acetylpyridine-4-boronic acid pinacol ester;1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]ethanone;

Chemical Property of 2-ACETYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 369.801 °C at 760 mmHg
• PKA: 2.58±0.10(Predicted)
• Flash Point: 177.449 °C
• PSA: 48.42000
• Density: 1.087 g/cm³
• LogP: 1.58340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Acetylpyridine-4-boronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ACETYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

There total 2 articles about 2-ACETYLPYRIDINE-4-BORONIC ACID PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-acetylpyridine (1122-62-9) + bis(pinacol)diborane (73183-34-3) → 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)ethan-1-one (741709-58-0)

Guidance literature:

bis(pinacol)diborane; With C₂₄H₂₈ClIrN₂O; In tetrahydrofuran; at 65 ℃; for 1h; Sealed tube; Inert atmosphere;

2-acetylpyridine; In tetrahydrofuran; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.0c04210

Reference yield:

1-(4-bromopyridin-2-yl)ethan-1-one (1060805-69-7) + bis(pinacol)diborane (73183-34-3) → 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)ethan-1-one (741709-58-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 100 ℃; for 1.5h; Microwave irradiation; Inert atmosphere; Sealed tube;

upstream raw materials:

1-(4-bromopyridin-2-yl)ethan-1-one

bis(pinacol)diborane

2-acetylpyridine

Refernces

• 1、 -. "SREBP INHIBITORS COMPRISING A 6-MEMBERED CENTRAL RING". Paragraph 0572. . Retrieved 2019/08/12.