(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

Base Information Edit

Chemical Name:(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide
CAS No.:1360552-09-5
Molecular Formula:C₁₆H₁₉N₅O
Molecular Weight:297.36
Hs Code.:
Mol file:1360552-09-5.mol

Synonyms:(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

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Chemical Property of (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide Edit

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Technology Process of (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

There total 12 articles about (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1360551-95-6
(R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

: 1360552-09-5
(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

Guidance literature:: With tripotassium phosphate "n" hydrate; di-tert-butylphosphinoferrocene tetrafluoroborate; 2CHO₃^(1-)*Pd⁽²⁺⁾; In isopropyl alcohol; at 80 ℃; for 4.5h; Inert atmosphere;
DOI:10.1021/jo502550h

Reference yield:

: 1360551-88-7
2-(4-bromo-phenyl)-2-cyclopropylpropionitrile

: 1360552-09-5
(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

Guidance literature:: Multi-step reaction with 3 steps

1: carbon dioxide / ethanol / Resolution of racemate

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 24 h / 80 °C

3: water; potassium hydroxide; hydroxylamine / 48 h / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon dioxide; water; hydroxylamine; sodium carbonate; potassium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

: 1360551-90-1
(R)-2-(4-bromo-phenyl)-2-cyclopropylpropionitrile

: 1360552-09-5
(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 24 h / 80 °C

2: water; potassium hydroxide; hydroxylamine / 48 h / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; hydroxylamine; sodium carbonate; potassium hydroxide; In tetrahydrofuran;