Technology Process of 4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenol
There total 5 articles about 4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 ℃;
for 0.5h;
DOI:10.1021/ml5001867
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium carbonate / ethanol / 5 h / Reflux
2: sodium hydroxide / methanol; tetrahydrofuran; water / 50 °C
3: boron trifluoride diethyl etherate / dimethyl sulfoxide / 20 h / 120 °C
4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / dimethyl sulfoxide / 80 °C / Inert atmosphere
5: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 0 °C
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; boron trifluoride diethyl etherate; dihydrogen peroxide; potassium acetate; sodium carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/ml5001867
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / dimethyl sulfoxide / 80 °C / Inert atmosphere
2: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0.5 h / 0 °C
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; dihydrogen peroxide; potassium acetate; sodium hydroxide;
In
tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1021/ml5001867