phenylhydrazone of ethyl ester of glyoxalic acid

Base Information

• Chemical Name: phenylhydrazone of ethyl ester of glyoxalic acid
• CAS No.: 80447-71-8
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• Mol file: 80447-71-8.mol

Synonyms:phenylhydrazone of ethyl ester of glyoxalic acid

Chemical Property of phenylhydrazone of ethyl ester of glyoxalic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of phenylhydrazone of ethyl ester of glyoxalic acid

There total 14 articles about phenylhydrazone of ethyl ester of glyoxalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

sodium diethylmalonate (996-82-7,34727-00-9,73177-21-6) + benzene diazonium chloride (100-34-5) → phenylhydrazono-malonic acid monoethyl ester (40885-79-8) + ethyl phenylhydrazono(phenyl)acetate (52328-57-1) + phenylhydrazone of ethyl ester of glyoxalic acid (80447-71-8) + diethyl 2-(phenylhydrazono)malonate (6134-59-4)

Guidance literature:

In ethanol; water; at 0 - 5 ℃;

Reference yield: 11.0%

ethyl (phenylhydrazono)chloroacetate (28663-68-5) → 1,4-diphenyl-1,4-dihydro-[1,2,4,5]tetrazine-3,6-dicarboxylic acid diethyl ester (4397-78-8) + phenylhydrazone of ethyl ester of glyoxalic acid (80447-71-8)

Guidance literature:

With lithium 2-phenylethynyltellurolate; triethylamine; In tetrahydrofuran; for 16h;

Reference yield:

ethyl 3-hydroxy-3-phenyl-2-(phenylhydrazono)propanoate (1268701-25-2) → ethyl 3-(2-ethoxycarbonyl-1-phenyl-2-(phenylhydrazono)ethoxy)-3-phenyl-2-(phenylhydrazono)propionate + benzaldehyde (100-52-7) + phenylhydrazone of ethyl ester of glyoxalic acid (80447-71-8)

Guidance literature:

at 200 ℃; for 0.5h; Sealed tube;

DOI:10.1016/j.tet.2010.11.074

upstream raw materials:

glyoxylic acid ethyl ester

phenylhydrazine hydrochloride

sodium diethylmalonate

benzene diazonium chloride

Downstream raw materials:

(R)-ethyl 6-methyl-1,4-diphenyl-1,4-dihydropyridazine-3-carboxylate

Refernces

• 1、 Ma, Chaowei,Wen, Ping,Li, Jihui,Han, Xu,Wu, Zhaoyang,Huang, Guosheng. "Palladium and Copper Cocatalyzed Intermolecular Cyclization Reaction: Synthesis of 5-Aminopyrazole Derivatives". supporting information. p. 1073 - 1077. Retrieved 2016/04/09.
• 2、 Fan, Xiu-Wei,Lei, Tao,Zhou, Chao,Meng, Qing-Yuan,Chen, Bin,Tung, Chen-Ho,Wu, Li-Zhu. "Radical Addition of Hydrazones by α-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis". . p. 7127 - 7133. Retrieved 2016/08/30.