2-oxo-1,2-diphenylethyl formate

Base Information

• Chemical Name: 2-oxo-1,2-diphenylethyl formate
• CAS No.: 82027-51-8
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.258
• Mol file: 82027-51-8.mol

Synonyms:2-oxo-1,2-diphenylethyl formate

Chemical Property of 2-oxo-1,2-diphenylethyl formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-oxo-1,2-diphenylethyl formate

There total 10 articles about 2-oxo-1,2-diphenylethyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + formic acid ethyl ester (109-94-4) → 2-oxo-1,2-diphenylethyl formate (82027-51-8)

Guidance literature:

With K5; for 0.5h; Heating;

DOI:10.1016/S0040-4020(01)00806-7

Reference yield: 67.0%

formic acid (64-18-6) + benzil (134-81-6) + triethyl phosphite (122-52-1) → 2-diethylphosphoryloxy-1,2-diphenylethanone (3491-28-9) + 2-oxo-1,2-diphenylethyl formate (82027-51-8) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2)

Guidance literature:

In N,N-dimethyl-formamide; at 23 - 26 ℃; for 0.00109167h; Solvent; Flow reactor; Inert atmosphere;

DOI:10.1002/ejoc.201901655

Reference yield: 67.0%

formic acid (64-18-6) + benzil (134-81-6) + triethyl phosphite (122-52-1) → 2-diethylphosphoryloxy-1,2-diphenylethanone (3491-28-9) + 2-oxo-1,2-diphenylethyl formate (82027-51-8)

Guidance literature:

In toluene; at 23 - 26 ℃; Concentration; Flow reactor; Inert atmosphere; Large scale;

DOI:10.1039/c9lc01099h

upstream raw materials:

formic acid

2-hydroxy-2-phenylacetophenone

2-oxo-1,2-diphenylethylmethanesulfonate

sodium formate

Downstream raw materials:

phenyl benzyl ketone

N-formylbenzamide

4,5-diphenyloxazole

Refernces

• 1、 Ramanjaneyulu, Bandaru T.,Vidyacharan, Shinde,Yim, Se Jun,Kim, Dong-Pyo. "Fast-Synthesis of α-Phosphonyloxy Ketones as Drug Scaffolds in a Capillary Microreactor". supporting information. p. 7730 - 7734. Retrieved 2019/12/24.
• 2、 Ghorbani-Choghamarani, Arash,Goudarziafshar, Hamid,Zamani, Parisa. "Polyvinylpolypyrrolidoniume tribromide as new and metal-free catalyst for the formylation and trimethylsilylation of hydroxyl group". scheme or table. p. 1207 - 1210. Retrieved 2012/01/05.