5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid

Base Information

• Chemical Name: 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid
• CAS No.: 881409-53-6
• Molecular Formula: C₈H₆F₃NO₃
• Molecular Weight: 221.136
• Mol file: 881409-53-6.mol

Synonyms:5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid

Chemical Property of 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid

Chemical Property:

• Boiling Point: 298.3±40.0 °C(Predicted)
• PKA: 0.91±0.50(Predicted)
• Density: 1.453±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid

There total 3 articles about 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (881409-53-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 70.0%

5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid methyl ester (1254199-82-0) → 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (881409-53-6)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 2h;

Reference yield:

methyl 5-hydroxypicolinate (30766-12-2) → 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (881409-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

1.2: 2.5 h / 0 - 20 °C

2.1: methanol; lithium hydroxide monohydrate / 2 h / Inert atmosphere

With methanol; lithium hydroxide monohydrate; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid methyl ester

methyl 5-hydroxypicolinate

Downstream raw materials:

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(2,2,2-trifluoroethoxy)-2-pyridinecarboxamide

5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

Refernces

• 1、 -. "BACE INHIBITORS". Paragraph 0195; 0196. . Retrieved 2015/01/06.
• 2、 -. "FUSED MULTI-CYCLIC SULFONE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF". Paragraph 0808; 0809; 0810; 0811. . Retrieved 2014/08/07.