2-(2-Hydroxy-1-phenylethyl)phenol

Base Information

• Chemical Name: 2-(2-Hydroxy-1-phenylethyl)phenol
• CAS No.: 109210-19-7
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.264
• European Community (EC) Number: 663-279-3
• ChEMBL ID: CHEMBL1795392
• Nikkaji Number: J2.260.815K
• Mol file: 109210-19-7.mol

Synonyms:2-(2-hydroxy-1-phenylethyl)phenol;SCHEMBL9326756;CHEMBL1795392;AKOS022651420;109210-19-7

Chemical Property of 2-(2-Hydroxy-1-phenylethyl)phenol

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 199

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CO)C2=CC=CC=C2O

Technology Process of 2-(2-Hydroxy-1-phenylethyl)phenol

There total 10 articles about 2-(2-Hydroxy-1-phenylethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C17H18O3 → GRI 513898 (109210-19-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/anie.201608937

Reference yield: 79.0%

C26H22Si (1355956-52-3) → GRI 513898 (109210-19-7)

Guidance literature:

With tert.-butylhydroperoxide; potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; decane; at 70 ℃; Inert atmosphere; Molecular sieve;

DOI:10.1021/ol203428c

Reference yield:

styrene oxide (96-09-3) + p-toluenesulfonic acid monohydrate (6192-52-5) → trans-4-Hydroxystilbene (6554-98-9) + AB_0000810 (53574-80-4) + GRI 513898 (109210-19-7) + 2-(4-hydroxy-phenyl)-2-phenyl-ethanol

Guidance literature:

at 70 ℃;

DOI:10.1021/ja01147a113

upstream raw materials:

styrene oxide

sodium phenoxide

3-phenyl-3H-benzofuran-2-one

p-toluenesulfonic acid monohydrate

Refernces

• 1、 Yu, Zhunzhun,Li, Yongfeng,Shi, Jiameng,Ma, Ben,Liu, Lu,Zhang, Junliang. "(C6F5)3B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with α-Aryl α-Diazoesters". supporting information. p. 14807 - 14811. Retrieved 2016/11/23.
• 2、 Bertolini, Ferruccio,Crotti, Paolo,Macchia, Franco,Pineschi, Mauro. "A new regio- and stereoselective intermolecular Friedel-Crafts alkylation of phenolic substrates with aryl epoxides". . p. 61 - 64. Retrieved 2007/10/03.