3-phenyl-1-benzofuran-2(3H)-one

Base Information

• Chemical Name: 3-phenyl-1-benzofuran-2(3H)-one
• CAS No.: 3117-37-1
• Molecular Formula: C14H10 O2
• Molecular Weight: 210.232
• Mol file: 3117-37-1.mol

Synonyms:Aceticacid, (o-hydroxyphenyl)phenyl-, g-lactone(6CI,7CI); 3-Phenyl-2(3H)-benzofuranone; 3-Phenylcoumaran-2-one;3-Phenylcoumaranone; Benzeneacetic acid, 2-hydroxy-a-phenyl-, g-lactone; NSC126366; NSC 17336

Chemical Property of 3-phenyl-1-benzofuran-2(3H)-one

Chemical Property:

• Vapor Pressure: 0.000564mmHg at 25°C
• Boiling Point: 311.4°Cat760mmHg
• Flash Point: 127.6°C
• Density: 1.234g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-phenyl-1-benzofuran-2(3H)-one

There total 32 articles about 3-phenyl-1-benzofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(hydroxy(phenyl)methyl)phenol (40473-50-5) + carbon monoxide (201230-82-2) → 3-phenyl-3H-benzofuran-2-one (3117-37-1)

Guidance literature:

With palladium diacetate; triphenylphosphine; trifluoroacetic acid; In benzene; at 125 ℃; for 20h; under 3800 Torr;

DOI:10.1021/jo9610873

Reference yield: 99.0%

C17H18O3 → 3-phenyl-3H-benzofuran-2-one (3117-37-1)

Guidance literature:

With trifluoroacetic acid; In toluene; at 90 ℃; for 5h;

DOI:10.1002/anie.201608937

Reference yield: 97.0%

N,N-Diethyl-2-(2-hydroxy-phenyl)-2-phenyl-acetamide (195210-78-7) → 3-phenyl-3H-benzofuran-2-one (3117-37-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 1h; Heating;

DOI:10.1055/s-1997-5743

upstream raw materials:

(2-hydroxy-phenyl)-phenyl-acetic acid

dioxo-2,2' tetrahydro-2,2',3,3' diphenyl-3,3' bisbenzofuranne-3,3'

benzyl alcohol

MANDELIC ACID

Downstream raw materials:

(+/-)-2-hydroxy-2-methyl-1-phenyl-1-(2-hydroxy-phenyl)-propane

3-(2-diethylamino-ethyl)-3-phenyl-3H-benzofuran-2-one

3-phenyl-3-(2-piperidino-ethyl)-3H-benzofuran-2-one

GRI 513898

Refernces

• 1、 Satoh, Tetsuya,Tsuda, Takatoshi,Kushino, Yuichi,Miura, Masahiro,Nomura, Masakatsu. "Synthesis of naphthofuran-2(3H)-one derivatives by palladium-catalyzed three-component coupling using naphthols, aldehydes, and carbon monoxide". . p. 6476 - 6477. Retrieved 1996.
• 2、 -. "A benzofuran compound and its efficient catalytic synthesis method". Paragraph 0019; 0020. . Retrieved 2019/04/04.
• 3、 Tanaka, Takafumi,Tanaka, Tsukushi,Tsuji, Taro,Yazaki, Ryo,Ohshima, Takashi. "Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer". supporting information. p. 3541 - 3544. Retrieved 2018/06/26.