Technology Process of (1beta,12alpha,15beta)-15-heptyl-1,11,12-trihydroxy-11,20-epoxypicras-3-ene-2,16-dione
There total 14 articles about (1beta,12alpha,15beta)-15-heptyl-1,11,12-trihydroxy-11,20-epoxypicras-3-ene-2,16-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 51 percent / p-toluenesulfonic acid / dimethylformamide / 84 h / 40 °C
2: 99 percent / pyridine / CHCl3 / 1.75 h
3: 1.) LDA, 2.) hexamethylphosphoric triamide / 1.) THF, -78 degC, 2 h. 2.) -20 degC to 0 degC
4: 99 percent / HCl / methanol / 0.25 h / Ambient temperature
5: Jones reagent / acetone / 0.05 h / Ambient temperature
6: aqueous HF / acetonitrile / 6 h / Ambient temperature
With
pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; jones reagent; hydrogen fluoride; toluene-4-sulfonic acid; lithium diisopropyl amide;
In
methanol; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)81638-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) LDA, 2.) hexamethylphosphoric triamide / 1.) THF, -78 degC, 2 h. 2.) -20 degC to 0 degC
2: 99 percent / HCl / methanol / 0.25 h / Ambient temperature
3: Jones reagent / acetone / 0.05 h / Ambient temperature
4: aqueous HF / acetonitrile / 6 h / Ambient temperature
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; jones reagent; hydrogen fluoride; lithium diisopropyl amide;
In
methanol; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)81638-0
