4-Amidinophenylmethanesulfonyl fluoride hydrochloride

Base Information

• Chemical Name: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
• CAS No.: 74938-88-8
• Molecular Formula: C₈H₉FN₂O₂S*ClH
• Molecular Weight: 252.697
• Hs Code.: 29252900
• Mol file: 74938-88-8.mol

Synonyms:Benzenemethanesulfonylfluoride, 4-(aminoiminomethyl)-, monohydrochloride (9CI);p-Amidinophenylmethanesulfonyl fluoride hydrochloride;4-Amidinophenylmethanesulfonyl fluoride hydrochloride;

Chemical Property of 4-Amidinophenylmethanesulfonyl fluoride hydrochloride

Chemical Property:

• Vapor Pressure: 5.85E-07mmHg at 25°C
• Melting Point: ~205 °C (dec.)
• Boiling Point: 405.2 °C at 760 mmHg
• Flash Point: 198.8 °C
• PSA: 92.39000
• LogP: 3.45280
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mM Stable when aliquoted at −20°C. Hal

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amidinophenylmethanesulfonyl fluoride hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Description: p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.

Technology Process of 4-Amidinophenylmethanesulfonyl fluoride hydrochloride

There total 1 articles about 4-Amidinophenylmethanesulfonyl fluoride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ((4-amidino)phenyl)methanesulphonyl fluoride hydrochloride (74938-88-8)

Guidance literature:

Reference yield:

Fmoc-Val-OH (68858-20-8) + ((4-amidino)phenyl)methanesulphonyl fluoride hydrochloride (74938-88-8) → C27H40N10O4S (1456610-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 0.33 h / 20 °C

1.3: 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 6-chloro-1-hydroxybenzotriazole; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dimethyl sulfoxide / 20 °C

2.2: TIS / 2 h / 30 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Downstream raw materials:

C₂₇H₄₀N₁₀O₄S

Refernces