1 6-BIS(P-CARBOXYPHENOXY)HEXANE

Base Information

• Chemical Name: 1 6-BIS(P-CARBOXYPHENOXY)HEXANE
• CAS No.: 74774-53-1
• Molecular Formula: C20H22O6
• Molecular Weight: 358.391
• Mol file: 74774-53-1.mol

Synonyms:Benzoicacid, 4,4'-(hexamethylenedioxy)di- (6CI);1,6-Bis(4-carboxyphenoxy)hexane;1,6-Hexyldioxy-4,4'-dibenzoic acid;a,w-Bis(4-carboxyphenoxy)hexane;4,4'-[Hexane-1,6-diylbis(oxy)]dibenzoic acid;

Chemical Property of 1 6-BIS(P-CARBOXYPHENOXY)HEXANE

Chemical Property:

• Melting Point: 278-290 °C
• Boiling Point: 580.1 °C at 760 mmHg
• PKA: 4.18±0.10(Predicted)
• Flash Point: 205.7 °C
• PSA: 93.06000
• Density: 1.238 g/cm³
• LogP: 4.10120

Purity/Quality:

99% ^*data from raw suppliers

1,6-Bis(p-carboxyphenoxy)hexane 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,N
• Hazard Codes: Xi,N
• Statements: 43-50/53
• Safety Statements: 36/37-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Building block for polyanhydrides, a class of bioerodible polymer with drug delivery applications.1

Technology Process of 1 6-BIS(P-CARBOXYPHENOXY)HEXANE

There total 7 articles about 1 6-BIS(P-CARBOXYPHENOXY)HEXANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,6-bis(4-carbethoxyphenoxy)hexane (56441-89-5) → 4,4'-dicarboxy-1,6-diphenoxyhexane (74774-53-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 90 ℃;

Reference yield: 70.0%

1 ,6-dibromohexane (629-03-8) + 4-hydroxy-benzoic acid (99-96-7) → 4,4'-dicarboxy-1,6-diphenoxyhexane (74774-53-1)

Guidance literature:

With sodium hydroxide; In water; for 6h; Reflux;

DOI:10.1016/j.reactfunctpolym.2010.05.003

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → 4,4'-dicarboxy-1,6-diphenoxyhexane (74774-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / cyclohexanone / 6 h / Heating

2: 15percent KOH / ethanol / 4 h / Heating

With potassium hydroxide; sodium carbonate; In ethanol; cyclohexanone;

upstream raw materials:

1,6-bis(4-carbethoxyphenoxy)hexane

1,6-dichlorohexane

4-hydroxy-benzoic acid

1 ,6-dibromohexane

Downstream raw materials:

4,4′-hexylenedioxydibenzoyl chloride

C₂₄H₂₆O₈

C₄₄H₅₄O₈

C₄₂H₅₀O₈

Refernces

• 1、 -. "Bent-core dimesogenic compound and method for preparing thereof". Paragraph 0114-0116. . Retrieved 2017/04/28.
• 2、 -. "CONTROLLED RELEASE FORMULATIONS FOR THE DELIVERY OF HIF-1 INHIBITORS". Page/Page column 73. . Retrieved 2013/09/26.