2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE

Base Information

• Chemical Name: 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE
• CAS No.: 74290-66-7
• Molecular Formula: C5H5Br2N3
• Molecular Weight: 266.9213
• Hs Code.: 2933990090
• Mol file: 74290-66-7.mol

Synonyms:Pyrazinamine,3,5-dibromo-6-methyl- (9CI);2-Amino-3,5-dibromo-6-methylpyrazine;3,5-Dibromo-6-methyl-2-pyrazinamine;3,5-Dibromo-6-methylpyrazin-2-ylamine;

Chemical Property of 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 167-168 °C
• Refractive Index: 1.661
• Boiling Point: 300.184 °C at 760 mmHg
• PKA: 1.11±0.10(Predicted)
• Flash Point: 135.347 °C
• PSA: 51.80000
• Density: 2.105 g/cm³
• LogP: 2.47340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dibromo-6-methylpyrazin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE

There total 3 articles about 2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-methylpyrazin-2-amine (5521-56-2) → 3,5-dibromo-6-methylpyrazin-2-ylamine (74290-66-7)

Guidance literature:

With pyridine; bromine; In dichloromethane; at 20 ℃;

Reference yield: 91.0%

6-methylpyrazin-2-amine (5521-56-2) → (5-bromo-6-methyl-pyrazin-2-yl)amine (74290-69-0) + 3,5-dibromo-6-methylpyrazin-2-ylamine (74290-66-7)

Guidance literature:

With pyridine; bromine; In chloroform; for 0.5h; Ambient temperature; in the dark;

Reference yield: 83.0%

2-chloro-6-methylpyrazine (38557-71-0) → 3,5-dibromo-6-methylpyrazin-2-ylamine (74290-66-7)

Guidance literature:

2-chloro-6-methylpyrazine; With ammonia; In water; at 180 ℃; for 8h;

With pyridine; bromine; In chloroform; at 20 ℃;

DOI:10.1016/j.bmcl.2017.05.028

upstream raw materials:

6-methylpyrazin-2-amine

2-chloro-6-methylpyrazine

Downstream raw materials:

N-(5-bromo-3-methoxy-6-methylpyrazin-2-yl)-2,3-dichlorobenzenesulfonamide

3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine

3-benzyl-5-(4-benzyloxy)phenyl-6-methylpyrazin-2-amine

3-benzyl-5-bromo-6-methylpyrazin-2-amine

Refernces

• 1、 -. "INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF". Paragraph 00500. . Retrieved 2018/07/05.
• 2、 -. "SYK INHIBITORS". Paragraph 0280. . Retrieved 2016/02/26.