4-(α-hydroxybenzyl)phenoxyacetic acid

Base Information

• Chemical Name: 4-(α-hydroxybenzyl)phenoxyacetic acid
• CAS No.: 117175-03-8
• Molecular Formula: C₁₅H₁₄O₄
• Molecular Weight: 258.274
• Mol file: 117175-03-8.mol

Synonyms:4-(α-hydroxybenzyl)phenoxyacetic acid

Chemical Property of 4-(α-hydroxybenzyl)phenoxyacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(α-hydroxybenzyl)phenoxyacetic acid

There total 5 articles about 4-(α-hydroxybenzyl)phenoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(α-hydroxybenzyl)phenoxyacetic ethyl ester (283165-06-0) → 4-(α-hydroxybenzyl)phenoxyacetic acid (117175-03-8)

Guidance literature:

With sodium hydroxide; In methanol; water;

DOI:10.1016/S0040-4039(00)00266-5

Reference yield:

4-hydroxy-benzhydrol (833-39-6) → 4-(α-hydroxybenzyl)phenoxyacetic acid (117175-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / K₂CO₃ / dimethylsulfoxide

2: 100 percent / NaOH / methanol; H₂O

With sodium hydroxide; potassium carbonate; In methanol; water; dimethyl sulfoxide; 1: Alkylation / 2: Hydrolysis;

DOI:10.1016/S0040-4039(00)00266-5

Reference yield:

2-(4-benzoylphenoxy)-acetic acid (6322-83-4) → 4-(α-hydroxybenzyl)phenoxyacetic acid (117175-03-8)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1016/j.tetlet.2003.12.160

upstream raw materials:

4-(α-hydroxybenzyl)phenoxyacetic ethyl ester

2-(4-benzoylphenoxy)-acetic acid

(4-benzoylphenoxy)acetic acid ethyl ester

4-Hydroxybenzophenone

Downstream raw materials:

<4-(α-chlorobenzyl)phenoxy>acetic acid

Refernces

• 1、 Goldstein, Alex S.,Gelb, Michael H.. "An alternate preparation of thioester resin linkers for solid-phase synthesis of peptide C-terminal thioacids". . p. 2797 - 2800. Retrieved 2007/10/03.