Triphenyl-(2-pyridinylmethyl)phosphonium bromide

Base Information

• Chemical Name: Triphenyl-(2-pyridinylmethyl)phosphonium bromide
• CAS No.: 73870-22-1
• Molecular Formula: C24H21 N P . Br
• Molecular Weight: 434.315
• DSSTox Substance ID: DTXSID90454856
• Mol file: 73870-22-1.mol

Synonyms:73870-22-1;Triphenyl(pyridin-2-ylmethyl)phosphonium bromide;TRIPHENYL-(2-PYRIDINYLMETHYL)PHOSPHONIUM BROMIDE;triphenyl(pyridin-2-ylmethyl)phosphanium;bromide;Phosphonium,triphenyl(2-pyridinylmethyl)-, bromide (1:1);SCHEMBL6484310;DTXSID90454856;AG-G-92843;FD10614;CS-0197715;FT-0699387

Chemical Property of Triphenyl-(2-pyridinylmethyl)phosphonium bromide

Chemical Property:

• PSA: 26.48000
• LogP: 1.57970
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 433.05950
• Heavy Atom Count: 27
• Complexity: 359

Purity/Quality:

98%min ^*data from raw suppliers

TRIPHENYL-(2-PYRIDINYLMETHYL)-PHOSPHONIUMBROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)[P+](CC2=CC=CC=N2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]

Technology Process of Triphenyl-(2-pyridinylmethyl)phosphonium bromide

There total 4 articles about Triphenyl-(2-pyridinylmethyl)phosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(Bromomethyl)pyridine (55401-97-3) + triphenylphosphine (603-35-0) → triphenyl(pyridine-2-ylmethyl)phosphonium bromide (73870-22-1)

Guidance literature:

In benzene; at 20 ℃; for 20h;

Reference yield: 74.3%

2-(bromomethyl)pyridine hydrobromide (31106-82-8) + triphenylphosphine (603-35-0) → triphenyl(pyridine-2-ylmethyl)phosphonium bromide (73870-22-1)

Guidance literature:

In toluene; Reflux;

Reference yield:

α-picoline (109-06-8) → triphenyl(pyridine-2-ylmethyl)phosphonium bromide (73870-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS; benzoyl proxide / CCl₄ / 18 h / 60 °C

2: 1.73 g / benzene / Heating

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; benzene;

DOI:10.1039/b109377k

upstream raw materials:

2-(Bromomethyl)pyridine

triphenylphosphine

α-picoline

2-(bromomethyl)pyridine hydrobromide

Downstream raw materials:

(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

4-(4-pyridin-2-ylmethylene-piperidin-1-yl)-benzoic acid

1,1,1-trifluoro-3-pyridin-2-yl-3-(triphenylphosphoranylidene)acetone

2-(1-(4-fluorobenzyl)-5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl)pyridine

Refernces

• 1、 Frydrych, Ivo,Urban, Milan,?arek, Jan,Benická, Sandra,D?ubák, Petr,Gurská, Soňa,Hajdúch, Marián,Kotulová, Jana,Li?ková, Barbora,Olejníková, Denisa,Pokorny, Jan. "Substituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters". . . Retrieved 2021/07/28.
• 2、 Mohideen, Mazlin,Zulkepli, Suraya,Nik-Salleh, Nik-Salmah,Zulkefeli, Mohd,Weber, Jean-Frédéric Faizal Abdullah,Rahman, A. F. M. Motiur. "Design, synthesis, in vitro cytotoxicity evaluation and structure-activity relationship of Goniothalamin analogs". . p. 812 - 831. Retrieved 2013/07/26.