55401-97-3Relevant articles and documents
Room-temperature Pd-catalyzed methoxycarbonylation of terminal alkynes with high branched selectivity enabled by bisphosphine-picolinamide ligand
Chen, Fen-Er,Ke, Miaolin,Liu, Ding,Ning, Yingtang,Ru, Tong
supporting information, p. 1041 - 1044 (2022/01/28)
We report the room-temperature Pd-catalyzed methoxy-carbonylation with high branched selectivity using a new class of bisphosphine-picolinamide ligands. Systematic optimization of ligand structures and reaction conditions revealed the significance of both
OX2R COMPOUNDS
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Paragraph 0473; 0474; 0512; 0513, (2019/10/19)
Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.
Synthesis method of 2-methoxy methylpyridine
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Paragraph 0023; 0024; 0027; 0028; 0029; 0030; 0033; 0034, (2017/10/13)
The invention relates to the field of organic chemistry and particularly relates to a synthesis method of 2-methoxy methylpyridine. The method comprises the following steps of (1) adopting 2-methylpyridine as a raw material and obtaining 2-bromo-methylpyridine through bromination reaction; (2) reacting the 2-bromo-methylpyridine and trimethylamine to obtain (2-pyridine methyl) trimethyl ammonium bromide; and (3) dissolving the (2-pyridine methyl) trimethyl ammonium bromide into methanol, adding sodium methoxide and carrying out heating refluxing under nitrogen for 1h to obtain the 2-methoxy methylpyridine. After adopting the synthesis method, the 2-methylpyridine is taken as the raw material, the 2-bromo-methylpyridine is obtained through bromination reaction, and the (2-pyridine methyl) trimethyl ammonium bromide is obtained through trimethylamine reaction and finally reacts with the sodium methoxide to obtain the 2-methoxy methylpyridine. The synthesis method is high in total yield, cheap in raw material, short in reaction time, mild in condition and simple in technological operation.