BenzaMide, 4-Methoxy-N-(phenylMethyl)-

Base Information

• Chemical Name: BenzaMide, 4-Methoxy-N-(phenylMethyl)-
• CAS No.: 7465-87-4
• Molecular Formula: C15H15 N O2
• Molecular Weight: 241.29
• Mol file: 7465-87-4.mol

Synonyms:p-Anisamide,N-benzyl- (6CI,7CI); 4-Methoxy-N-(phenylmethyl)benzamide;N-Benzyl-4-methoxybenzamide; N-Benzyl-p-methoxybenzamide; NSC 404047

Chemical Property of BenzaMide, 4-Methoxy-N-(phenylMethyl)-

Chemical Property:

• Vapor Pressure: 5.56E-08mmHg at 25°C
• Boiling Point: 441.2°Cat760mmHg
• Flash Point: 220.6°C
• PSA: 38.33000
• Density: 1.124g/cm³
• LogP: 3.01610
• Water Solubility.: Soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

N-BENZYL-4-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BenzaMide, 4-Methoxy-N-(phenylMethyl)-

There total 143 articles about BenzaMide, 4-Methoxy-N-(phenylMethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloromethoxybenzene (623-12-1) + carbon monoxide (201230-82-2) + benzylamine (100-46-9) → N-benzyl-4-methoxybenzamide (7465-87-4)

Guidance literature:

With 4 A molecular sieve; sodium phenoxide; palladium diacetate; In dimethyl sulfoxide; at 110 ℃; for 15h; under 760.051 Torr;

DOI:10.1002/anie.200702943

Reference yield: 96.0%

4-Methoxybenzyl alcohol (105-13-5) + benzylamine (100-46-9) → N-benzyl-4-methoxybenzamide (7465-87-4)

Guidance literature:

With 3-methyl-butan-2-one; caesium carbonate; In tert-butyl alcohol; for 18h; Reflux; Inert atmosphere;

DOI:10.1002/aoc.3233

Reference yield: 95.0%

p-nitrophenyl p-methoxybenzoate (7464-46-2) + benzylamine (100-46-9) → N-benzyl-4-methoxybenzamide (7465-87-4)

Guidance literature:

p-nitrophenyl p-methoxybenzoate; With 1,3-dimethylimidazolim iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 0.333333h; Schlenk technique;

benzylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1055/s-0037-1610355

upstream raw materials:

3,7-bis-(4-methoxy-benzoyl)-2,8-bis-(4-methoxy-phenyl)-pyrano[3,2-g]chromene-4,6-dione

benzylamine

4-methoxy-benzoyl chloride

ethyl 3-(benzylamino)crotonate

Downstream raw materials:

N-benzyl-4-methoxybenzenecarbothioamide

N-[(1H-1,2,3-benzotriazol-1-yl)(4-methoxyphenyl)methylidene]-N-benzylamine

4-benzyl-5-(4-methoxyphenyl)-3-(2',3',4',6'-tetra-O-benzoyl-β-D-glucopyranosyl)-1,2,4-triazole

N-(phenylmethyl)acetamide

Refernces

• 1、 Boyle, Mhairi,Livingstone, Keith,Henry, Martyn C.,Elwood, Jessica M. L.,Lopez-Fernandez, J. Daniel,Jamieson, Craig. "Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides". . p. 334 - 338. Retrieved 2022/01/20.
• 2、 Xu-Xu, Qing-Feng,Nishii, Yuji,Uetake, Yuta,Sakurai, Hidehiro,Miura, Masahiro. "Synthesis of Benzoisoselenazolones via Rh(III)-Catalyzed Direct Annulative Selenation by Using Elemental Selenium". supporting information. p. 17952 - 17959. Retrieved 2021/11/16.