benzoylthioacetic acid piperide

Base Information

• Chemical Name: benzoylthioacetic acid piperide
• CAS No.: 53354-69-1
• Molecular Formula: C₁₄H₁₇NOS
• Molecular Weight: 247.361
• Mol file: 53354-69-1.mol

Synonyms:benzoylthioacetic acid piperide

Chemical Property of benzoylthioacetic acid piperide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoylthioacetic acid piperide

There total 4 articles about benzoylthioacetic acid piperide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperidine (110-89-4) + methyl 3-oxo-3-phenylpropanedithioate (20365-21-3) → benzoylthioacetic acid piperide (53354-69-1)

Guidance literature:

In ethanol; for 2h; Reflux;

DOI:10.1002/ejoc.201101397

Reference yield: 88.0%

piperidine (110-89-4) + β-hydroxy dithiocinnamic methyl ester (17666-73-8) → benzoylthioacetic acid piperide (53354-69-1)

Guidance literature:

In ethanol; for 7h; Heating;

Reference yield:

acetophenone (98-86-2) → benzoylthioacetic acid piperide (53354-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / hexane; N,N-dimethyl-formamide / 20 °C

2: ethanol / 2 h / Reflux

With sodium hydride; In ethanol; hexane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201101397

upstream raw materials:

piperidine

β-hydroxy dithiocinnamic methyl ester

methyl 3-oxo-3-phenylpropanedithioate

acetophenone

Downstream raw materials:

phenyl(4-phenyl-2-(piperidin-1-yl)thiophen-3-yl)methanone

Refernces

• 1、 Vishwakarma, J. N.,Apparao, S.,Ila, H.,Junjappa, H.. "Reactions of Polarized Keten S,N-Acetals with Guanidine: A Facile General Route to Novel 5,6-Substituted 2-Amino-4-N-alkyl/aryl/N-azacycloalkylaminopyrimidines". . p. 466 - 471. Retrieved 2007/10/02.