Technology Process of 1,1,1-trifluoro-2-(4-(4-(1-tosylpiperidin-4-yl)oxazol-5-yl)phenyl)propan-2-ol
There total 6 articles about 1,1,1-trifluoro-2-(4-(4-(1-tosylpiperidin-4-yl)oxazol-5-yl)phenyl)propan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol;
at 80 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 4 h / 0 °C
2: Dess-Martin periodane / tetrahydrofuran; dichloromethane / 24 h / 0 - 20 °C
3: sodium methylate / methanol / 2 h / 80 °C
With
lithium aluminium tetrahydride; sodium methylate; Dess-Martin periodane;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
2: Dess-Martin Oxidation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / 12 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.42 h / 0 - 20 °C
2.2: 16 h / 20 °C
3.1: sodium methylate / methanol / 2 h / 80 °C
With
pyridine; sodium methylate; sodium hydride;
In
methanol; N,N-dimethyl-formamide;