1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid

Base Information

• Chemical Name: 1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid
• CAS No.: 1567898-20-7
• Molecular Formula: C₁₉H₂₈N₂O₅S
• Molecular Weight: 396.508
• Mol file: 1567898-20-7.mol

Synonyms:1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid

Chemical Property of 1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid

There total 4 articles about 1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Spiro<4.5>decan-2,4'-oxazolidine-2,5'-dione (3253-43-8) + N,N-diethyl-4-methylbenzenesulfonamide (649-15-0) → 1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid (1567898-20-7)

Guidance literature:

N,N-diethyl-4-methylbenzenesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

Spiro<4.5>decan-2,4'-oxazolidine-2,5'-dione; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol500523n

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid (1567898-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1021/ol500523n

Reference yield:

1-tert-butoxycarbonylaminocyclohexanecarboxylic acid (115951-16-1) → 1-(2-(N,N-diethylsulfamoyl)-5-methylbenzamido)cyclohexanecarboxylicacid (1567898-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus trichloride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; phosphorus trichloride; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol500523n

upstream raw materials:

1-aminocyclohexane carboxylic acid

1-tert-butoxycarbonylaminocyclohexanecarboxylic acid

1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid

Spiro<4.5>decan-2,4'-oxazolidine-2,5'-dione

Refernces