Technology Process of tert-butyl-[4-{5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-1-(1-methoxymethoxyheptyl)-but-3-ynyloxy]-dimethylsilane
There total 18 articles about tert-butyl-[4-{5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-1-(1-methoxymethoxyheptyl)-but-3-ynyloxy]-dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
dichloromethane;
at 0 ℃;
for 0.5h;
DOI:10.1021/jo050193e
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 89 percent / triphenylphosphine; N-chlorosuccinimide / CH2Cl2 / 0 - 20 °C
2: 96 percent / potassium ferricyanide; potassium carbonate; K2OsO2(OH)4 / (DHQD)2PHAL; methanesulfonamide / 2-methyl-propan-2-ol; H2O; toluene / 10 h / 0 °C
3: 90 percent / NaOH / tetrahydrofuran / 2 h / 0 - 20 °C
4: 98 percent / diisopropylethylamine / CH2Cl2 / 6 h / 0 - 20 °C
5: 89 percent / n-BuLi; BF3*Et2O / tetrahydrofuran; hexane / 0.5 h / -78 °C
6: 98 percent / 2,6-lutidine / CH2Cl2 / 0.5 h / 0 °C
With
2,6-dimethylpyridine; sodium hydroxide; N-chloro-succinimide; n-butyllithium; potassium dioxotetrahydroxoosmate(VI); boron trifluoride diethyl etherate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hexacyanoferrate(III);
methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tetrahydrofuran; hexane; dichloromethane; water; toluene; tert-butyl alcohol;
2: Sharpless asymmetric dihydroxylation / 5: Yamaguchi coupling;
DOI:10.1021/jo050193e
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / Li; NH3; Fe(NO3)3 / tetrahydrofuran / -78 °C
2: 96 percent / LiAlH4 / tetrahydrofuran / Heating
3: 89 percent / triphenylphosphine; N-chlorosuccinimide / CH2Cl2 / 0 - 20 °C
4: 96 percent / potassium ferricyanide; potassium carbonate; K2OsO2(OH)4 / (DHQD)2PHAL; methanesulfonamide / 2-methyl-propan-2-ol; H2O; toluene / 10 h / 0 °C
5: 90 percent / NaOH / tetrahydrofuran / 2 h / 0 - 20 °C
6: 98 percent / diisopropylethylamine / CH2Cl2 / 6 h / 0 - 20 °C
7: 89 percent / n-BuLi; BF3*Et2O / tetrahydrofuran; hexane / 0.5 h / -78 °C
8: 98 percent / 2,6-lutidine / CH2Cl2 / 0.5 h / 0 °C
With
2,6-dimethylpyridine; sodium hydroxide; N-chloro-succinimide; lithium aluminium tetrahydride; n-butyllithium; potassium dioxotetrahydroxoosmate(VI); boron trifluoride diethyl etherate; ammonia; lithium; potassium carbonate; ferric nitrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hexacyanoferrate(III);
methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tetrahydrofuran; hexane; dichloromethane; water; toluene; tert-butyl alcohol;
4: Sharpless asymmetric dihydroxylation / 7: Yamaguchi coupling;
DOI:10.1021/jo050193e