Technology Process of methyl 3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl) butanoate
There total 3 articles about methyl 3-(benzyloxyamino)-4-(2,4,5-trifluorophenyl) butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
O-benzylhydoxylamine hydrochloride;
With
sodium hydroxide;
In
water;
for 0.25h;
(E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester;
With
dodecylbenzene-sulphonic acid;
at 60 - 80 ℃;
for 30h;
Reagent/catalyst;
Temperature;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 - -10 °C / Inert atmosphere
1.2: -20 - 0 °C / Inert atmosphere
2.1: sodium hydroxide / water / 0.25 h
2.2: 24 h / 60 °C
With
isopropylmagnesium chloride; sodium hydroxide;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N,N,N,N,-tetramethylethylenediamine; cobalt(II) bromide / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
2: sodium hydroxide / para-dodecylbenzenesulfonic acid / water / 29 h / 60 - 80 °C
With
sodium hydroxide;
N,N,N,N,-tetramethylethylenediamine; para-dodecylbenzenesulfonic acid; cobalt(II) bromide;
In
tetrahydrofuran; water;