Technology Process of (S)-(E)-3-(3,4-Dihydroxy-5-methoxybenzyl)-2-(3,4,5-trimethoxybenzylidene)butanolide
There total 11 articles about (S)-(E)-3-(3,4-Dihydroxy-5-methoxybenzyl)-2-(3,4,5-trimethoxybenzylidene)butanolide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 2 steps
1: 1.) diisopropylamine, n-butyllithium; 2.) triethylamine, acetic anhydride, dimethylaminopyridine; 3.) 1,8-diazabicyclo<5.4.0>undec-7-ene / 1.) THF, -70 deg C, 5 min; 2.) CH2Cl2, r.t., 1 h; 3.) toluene, 80 deg C, 1.5 h
2: 1.) BCl3; 2.) 2N HCl / 1.) CH2Cl2, 0 deg C, 30 min; 2.) MeOH, r.t., 2 h
With
hydrogenchloride; dmap; n-butyllithium; acetic anhydride; boron trichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; diisopropylamine;
DOI:10.3987/com-95-s45
- Guidance literature:
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Multi-step reaction with 4 steps
1: 84 percent / Rh(COD)2BF4, (R,R)-MOD-DIOP, Et3N, hydrogen / methanol / 42 h / Ambient temperature
2: 93 percent / KOH, CaCl2, NaBH4 / ethanol / 12 h / 0 °C
4: 97 percent / BCl3 / CH2Cl2 / 0.5 h / 0 °C
With
potassium hydroxide; sodium tetrahydroborate; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; hydrogen; boron trichloride; (4R-trans)-<(2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene)>bis; triethylamine; calcium chloride;
In
methanol; ethanol; dichloromethane;
DOI:10.1016/0040-4020(95)00702-A
