SchisandrinB

Base Information Edit

Chemical Name:SchisandrinB
CAS No.:58546-54-6
Molecular Formula:C₂₃H₂₈O₇
Molecular Weight:416.471
Hs Code.:29329990
European Community (EC) Number:878-647-0
ChEMBL ID:CHEMBL1159658
Metabolomics Workbench ID:122345
Nikkaji Number:J733.716G
Wikidata:Q104392454
Wikipedia:Gomisin_A
Mol file:58546-54-6.mol

Synonyms:5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11-methylenedioxy-6-dibenzo(a,c)cyclooctenol;gomisin A;schisandrol B;schizandrol B;TJN 101;TJN-101

Suppliers and Price of SchisandrinB

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Schizandrol B
20mg
$ 320.00

Usbiological
Schizandrol B
1mg
$ 305.00

TRC
SchizandrolB
1mg
$ 45.00

TRC
SchizandrolB
2.5mg
$ 65.00

TCI Chemical
Gomisin A
5MG
$ 90.00

TCI Chemical
Gomisin A
25MG
$ 323.00

Medical Isotopes, Inc.
SchizandrolB 98%
20 mg
$ 483.00

Labseeker
Gomisin A 98
1g
$ 1651.00

JR MediChem
Schisandrol?B 98%
20mg
$ 148.00

DC Chemicals
Gomisin A >98%,StandardReferencesGrade
250 mg
$ 850.00

Total 83 raw suppliers

Chemical Property of SchisandrinB Edit

Chemical Property:

Vapor Pressure:2.79E-14mmHg at 25°C
Melting Point:88.5°C
Refractive Index:1.56
Boiling Point:579.7 °C at 760 mmHg
PKA:14.58±0.40(Predicted)
Flash Point:304.4 °C
PSA：75.61000
Density:1.21 g/cm³
LogP:3.60240
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:416.18350323
Heavy Atom Count:30
Complexity:588

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Schizandrol B ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4CC1(C)O)OC)OC)OC)OC)OCO3
Isomeric SMILES:C[C@H]1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4C[C@@]1(C)O)OC)OC)OC)OC)OCO3
Description Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .
Uses Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.

Technology Process of SchisandrinB

There total 20 articles about SchisandrinB which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%