Technology Process of 4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide
There total 4 articles about 4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos;
In
1,4-dioxane;
at 100 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / 1 h / 0 - 10 °C
2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 0 - 80 °C
3: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
With
pyridine; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; caesium carbonate; sodium t-butanolate; ruphos;
In
1,4-dioxane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / 1 h / 0 - 10 °C
2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 0 - 80 °C
3: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
With
pyridine; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; caesium carbonate; sodium t-butanolate; ruphos;
In
1,4-dioxane; N,N-dimethyl-formamide;