Technology Process of benzyl (2,6-dichloropyridin-4-yl)(2-methylallyl)carbamate
There total 6 articles about benzyl (2,6-dichloropyridin-4-yl)(2-methylallyl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2,6-dichloropyridin-4-yl)carbamic acid benzyl ester;
With
tetra-(n-butyl)ammonium iodide; sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.0833333h;
2-methyl-3-bromo-1-propene;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1021/ol801860s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / tetrahydrofuran / 2 h / Reflux
2.1: sodium azide / water; acetone / 0 - 10 °C
3.1: magnesium sulfate / toluene / 15 h / Reflux
4.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 0.08 h / 0 °C
4.2: 20 °C
With
sodium azide; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; magnesium sulfate;
In
tetrahydrofuran; water; acetone; toluene;
2.1: Curtius rearrangement;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichlorophosphate / 18 h / 130 °C
2.1: lithium hydroxide / tetrahydrofuran; water / 0.33 h / 20 °C
2.2: 2 h / 0 °C
3.1: oxalyl dichloride / tetrahydrofuran / 2 h / Reflux
4.1: sodium azide / water; acetone / 0 - 10 °C
5.1: magnesium sulfate / toluene / 15 h / Reflux
6.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 0.08 h / 0 °C
6.2: 20 °C
With
sodium azide; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; magnesium sulfate; lithium hydroxide; trichlorophosphate;
In
tetrahydrofuran; water; acetone; toluene;
4.1: Curtius rearrangement;
