N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester

Base Information

• Chemical Name: N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester
• CAS No.: 129460-14-6
• Molecular Formula: C₂₈H₃₅NO₆
• Molecular Weight: 481.589
• Mol file: 129460-14-6.mol

Synonyms:N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester

Chemical Property of N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

FMOC-GLU(OTBU)-OTBU 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester

There total 2 articles about N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-2-[{({9H-fluoren-9-yl}methoxy)carbonyl}amino]pentanedioic acid (104091-09-0,136083-74-4,121343-82-6) + isobutene (115-11-7,15220-85-6) → N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester (129460-14-6)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 48h;

DOI:10.1055/s-1990-26943

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + 9-fluorenylmethyl N-succinimidyl carbonate (102774-86-7) + isobutene (115-11-7,15220-85-6) → Fmoc-Glu-OtBu (84793-07-7) + Fmoc-Glu(OtBu)-OH (71989-18-9) + N-(9-fluorenylmethoxycarbonyl)glutamic acid di-tert-butyl ester (129460-14-6)

Guidance literature:

With sodium carbonate; toluene-4-sulfonic acid; Yield given. Multistep reaction. Yields of byproduct given; 1) dioxane, gas pressure: 350 mbar, 3 d, r.t., 2) dioxane, 0 deg C to r.t., 14 h;

DOI:10.1055/s-1990-26943

upstream raw materials:

L-glutamic acid

9-fluorenylmethyl N-succinimidyl carbonate

isobutene

(S)-2-[{({9H-fluoren-9-yl}methoxy)carbonyl}amino]pentanedioic acid

Refernces